Quality and Reporting of Diagnostic Accuracy Studies in TB, HIV and Malaria Evaluation Using QUADAS and STARD Standards 英文参考文献.docVIP

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Quality and Reporting of Diagnostic Accuracy Studies in TB, HIV and Malaria Evaluation Using QUADAS and STARD Standards 英文参考文献.doc

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Quality and Reporting of Diagnostic Accuracy Studies in TB, HIV and Malaria Evaluation Using QUADAS and STARD Standards 英文参考文献

QualityandReportingofDiagnosticAccuracyStudiesin TB,HIVandMalaria:EvaluationUsingQUADASand STARDStandards PatriciaScolariFontela1,NitikaPantPai2,IanSchiller2,NandiniDendukuri2,AndrewRamsay3, MadhukarPai1,4 * 1DepartmentofEpidemiology,BiostatisticsandOccupationalHealth,McGillUniversity,Montreal,Canada,2DepartmentofMedicine,DivisionofClinicalEpidemiology, McGillUniversity,Montreal,Canada,3SpecialProgrammeforResearchandTraininginTropicalDiseases,WorldHealthOrganization,Geneva,Switzerland,4Respiratory EpidemiologyandClinicalResearchUnit,MontrealChestInstitute,Montreal,Canada Abstract Background:Poormethodologicalqualityandreportingareknownconcernswithdiagnosticaccuracystudies.In2003,the QUADAStoolandtheSTARDstandardswerepublishedforevaluatingthequalityandimprovingthereportingofdiagnostic studies, respectively. However, it is unclear whether these tools have been applied to diagnostic studies of infectious diseases. We performed a systematic review on the methodological and reporting quality of diagnostic studies in TB, malariaandHIV. Methods:WeidentifieddiagnosticaccuracystudiesofcommercialtestsforTB,malariaandHIVthroughasystematicsearch oftheliteratureusingPubMedandEMBASE(2004–2006).Originalstudiesthatreportedsensitivityandspecificitydatawere included.Tworeviewersindependentlyextracteddataonstudycharacteristicsanddiagnosticaccuracy,andusedQUADAS andSTARDtoevaluatethequalityofmethodsandreporting,respectively. Findings:Ninety(38%)of238articlesmetinclusioncriteria.Allstudieshaddesigndeficiencies.Studyqualityindicatorsthat weremetinlessthan25%ofthestudiesincludedadequatedescriptionofwithdrawals(6%)andreferencetestexecution (10%),absenceofindextestreviewbias(19%)andreferencetestreviewbias(24%),andreportofuninterpretableresults (22%). In terms of quality of reporting, 9 STARD indicators were reported in less than 25% of the studies: methods for calculation and estimates of reproducibility (0%), adverse effects of the diagnostic tests (1%), estimates of diagnostic accuracyb