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Quality of life is predictive of relapse in schizophrenia 英文参考文献
Boyeretal.BMCPsychiatry2013,13:15
/1471-244X/13/15
RESEARCH ARTICLE
OpenAccess
Qualityoflifeispredictiveofrelapsein
schizophrenia
LaurentBoyer1*,AurelieMillier2,EmelinePerthame2,SamuelAballea2,PascalAuquier1andMondherToumi3
Abstract
Background:Theobjectiveofthisstudywastoevaluatewhetherqualityoflife(QoL),asmeasuredbytheSF36
andtheQualityofLifeInterview(QoLI),ispredictiveofrelapseforpatientswithschizophrenia.
Methods:UsingdatafromamulticentercohortstudyconductedinFrance,Germany,andtheUnited-Kingdom
(EuroSC),weperformedCoxproportional-hazardsmodelstoestimatetheassociationsbetweenQoLatbaseline
andtheoccurrenceofrelapseovera24-monthperiod,withadjustmentforage;gender;positive,negativeand
generalpsychopathologyPANSSfactors;functioning(GAF);medication;side-effects;andcompliancemeasures.
Results:Oursampleconsistedof1,024patients;540(53%)hadatleastoneperiodofrelapse,and484(47%)had
norelapse.QoLlevelswerethemostimportantfeaturespredictingrelapse.WefoundthatahigherlevelofQoL
predictsalowerrateofrelapseat24months:HR=0.82(0.74;0.91),p0.001fortheSF36-PhysicalCompositeScore;
andHR=0.88(0.81;0.96),p=0.002fortheSF36-MentalCompositeScore.Theseresultswerenotconfirmedusing
theQoLI:HR=0.91(0.81;1.01),p=0.083.Toalesserextent,olderage,betterfunctioning,andahighercompliance
scorealsopredictalowerrateofrelapseat24months(HRsfrom0.97to0.98;p0.05).
Conclusions:QoL,asassessedbytheSF36,isanindependentpredictorofrelapseata24-monthfollow-upin
schizophrenia.ThisfindingmayhaveimplicationsforfutureuseoftheQoLinpsychiatry.Moreover,ourfindings
maysupportthedevelopmentandmonitoringofcomplementarytherapeuticapproaches,suchas‘recovery-
oriented’combinedwithtraditionalmentalhealthcarestopreventrelapse.
Keywords:Schizophrenia,Qualityoflife,Relapse,Compliance,Functioning,Recovery
Background
these factors imperfectly predict relapse, and the relapse
Schizophrenia isa severeandchronic mentalillnessthat rate still remains high. Other factors, such as social and
is characterized by recurrent relapses [1,2]
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