Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients a prospective validation study 英文参考文献.docVIP

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Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients a prospective validation study 英文参考文献.doc

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Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients a prospective validation study 英文参考文献

Available online /content/9/6/R601 Research Open Access Vol 9 No 6 Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study E Christiaan Boerma1,2, Keshen R Mathura1, Peter HJ van der Voort2, Peter E Spronk1,3 and Can Ince1 1Department of Physiology, Academic Medical Centre, University of Amsterdam, The Netherlands 2Department of Intensive Care, Medical Centre Leeuwarden, The Netherlands 3Department of Intensive Care, Gelre Ziekenhuizen Apeldoorn, The Netherlands Corresponding author: E Christiaan Boerma, e.boerma@chello.nl Received: 10 Aug 2005 Accepted: 25 Aug 2005 Published: 22 Sep 2005 Critical Care 2005, 9:R601-R606 (DOI 10.1186/cc3809) This article is online at: /content/9/6/R601 ? 2005 Boerma et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The introduction of orthogonal polarization and stoma region were obtained, processed and analysed in a standardised way. We validated intra-observer and inter- observer reproducibility with kappa cross-tables for both types of microvascular beds. spectral (OPS) imaging in clinical research has elucidated new perspectives on the role of microcirculatory flow abnormalities in the pathogenesis of sepsis. Essential to the process of understanding and reproducing these abnormalities is the method of quantification of flow scores. Results Agreement and kappa coefficients were 85% and 0.75, respectively, for interrater and intrarater variability in quantification of flow abnormalities during sepsis, in different subsets of microvascular architecture. Methods In a consensus meeting with collaboraters from six research centres in different fields