Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics 英文参考文献.docVIP

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Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics 英文参考文献.doc

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QuantitativeAnalysisofPeripheralTissuePerfusion UsingSpatiotemporalMolecularDynamics YujungKang1.,MyunghwanChoi1.,JungsulLee1,GouYoungKoh2,3,4,KihwanKwon5 ,Chulhee Choi1,3,4 * 1DepartmentofBioandBrainEngineering,KAIST,Daejeon,Korea,2DepartmentofBiologicalSciences,KAIST,Daejeon,Korea,3GraduateSchoolofMedicalScienceand Engineering,KAIST,Daejeon,Korea,4KIfortheBioCentury,KAIST,Daejeon,Korea, 5DepartmentofCardiology,SchoolofMedicine,EwhaWomansUniversity,Seoul, Korea Abstract Background: Accurate measurement of peripheral tissue perfusion is challenging but necessary to diagnose peripheral vascularinsufficiency.Becausenearinfrared(NIR)radiationcanpenetraterelativelydeepintotissue,significantattention hasbeengiventointravitalNIRfluorescenceimaging. Methodology/Principal Findings: We developeda new optical imaging-based strategy for quantitative measurement of peripheraltissueperfusionbytime-seriesanalysisoflocalpharmacokineticsoftheNIRfluorophore,indocyaninegreen(ICG). Time-seriesNIRfluorescenceimageswereobtainedafterinjectingICGintravenouslyinamurinehindlimbischemiamodel. Mathematicalmodelingandcomputationalsimulationswereusedfortranslatingtime-seriesICGimagesintoquantitative pixelperfusionratesandaperfusionmap.Wecouldsuccessfullypredicttheprognosisofischemichindlimbsbasedonthe perfusionprofilesobtainedimmediatelyaftersurgery,whichweredependentonthepreexistingcollaterals.Thismethod also reflected increases in perfusion and improvements in prognosis of ischemic hindlimbs induced by treatment with vascularendothelialgrowthfactorandCOMP-angiopoietin-1. Conclusions/Significance:WeproposethatthisnovelNIR-imaging-basedstrategyisapowerfultoolforbiomedicalstudies relatedtotheevaluationoftherapeuticinterventionsdirectedatstimulatingangiogenesis. Citation:KangY,ChoiM,LeeJ,KohGY,KwonK,etal.(2009)QuantitativeAnalysisofPeripheralTissuePerfusionUsingSpatiotemporalMolecularDynamics.PLoS ONE4(1):e4275.doi:10.1371/journal.pone.0004275 Editor:TimothySecomb,UniversityofArizona,Unit