Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics 英文参考文献.docVIP
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QuantitativeAnalysisofPeripheralTissuePerfusion
UsingSpatiotemporalMolecularDynamics
YujungKang1.,MyunghwanChoi1.,JungsulLee1,GouYoungKoh2,3,4,KihwanKwon5 ,Chulhee
Choi1,3,4
*
1DepartmentofBioandBrainEngineering,KAIST,Daejeon,Korea,2DepartmentofBiologicalSciences,KAIST,Daejeon,Korea,3GraduateSchoolofMedicalScienceand
Engineering,KAIST,Daejeon,Korea,4KIfortheBioCentury,KAIST,Daejeon,Korea, 5DepartmentofCardiology,SchoolofMedicine,EwhaWomansUniversity,Seoul,
Korea
Abstract
Background: Accurate measurement of peripheral tissue perfusion is challenging but necessary to diagnose peripheral
vascularinsufficiency.Becausenearinfrared(NIR)radiationcanpenetraterelativelydeepintotissue,significantattention
hasbeengiventointravitalNIRfluorescenceimaging.
Methodology/Principal Findings: We developeda new optical imaging-based strategy for quantitative measurement of
peripheraltissueperfusionbytime-seriesanalysisoflocalpharmacokineticsoftheNIRfluorophore,indocyaninegreen(ICG).
Time-seriesNIRfluorescenceimageswereobtainedafterinjectingICGintravenouslyinamurinehindlimbischemiamodel.
Mathematicalmodelingandcomputationalsimulationswereusedfortranslatingtime-seriesICGimagesintoquantitative
pixelperfusionratesandaperfusionmap.Wecouldsuccessfullypredicttheprognosisofischemichindlimbsbasedonthe
perfusionprofilesobtainedimmediatelyaftersurgery,whichweredependentonthepreexistingcollaterals.Thismethod
also reflected increases in perfusion and improvements in prognosis of ischemic hindlimbs induced by treatment with
vascularendothelialgrowthfactorandCOMP-angiopoietin-1.
Conclusions/Significance:WeproposethatthisnovelNIR-imaging-basedstrategyisapowerfultoolforbiomedicalstudies
relatedtotheevaluationoftherapeuticinterventionsdirectedatstimulatingangiogenesis.
Citation:KangY,ChoiM,LeeJ,KohGY,KwonK,etal.(2009)QuantitativeAnalysisofPeripheralTissuePerfusionUsingSpatiotemporalMolecularDynamics.PLoS
ONE4(1):e4275.doi:10.1371/journal.pone.0004275
Editor:TimothySecomb,UniversityofArizona,Unit
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