Quantitative ColourDopplerSonography Evaluation of Cerebral Venous Outflow A Comparative Study between Patients with Multiple Sclerosis and Controls 英文参考文献.docVIP
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Quantitative ColourDopplerSonography Evaluation of Cerebral Venous Outflow A Comparative Study between Patients with Multiple Sclerosis and Controls 英文参考文献
QuantitativeColourDopplerSonographyEvaluationof
CerebralVenousOutflow:AComparativeStudybetween
PatientswithMultipleSclerosisandControls
LuciaMonti1*,ElisabettaMenci1,MonicaUlivelli2,AlfonsoCerase1,SabinaBartalini2,PietroPiu2 ,Nicola
Marotti1,SaraLeonini1,PaoloGalluzzi1,DanieleG.Romano1,AlfredoE.Casasco3,CarloVenturi1
1UnitofNeuroimagingandNeurointervention,DepartmentofNeurologicalandSensorialSciences, AziendaOspedaliera Universitaria Senese,Santa MariaalleScotte
GeneralHospital,Siena,Italy,2DepartmentofNeurosciences,UniversityofSiena,Siena,Italy,3UnitofEndovascularandPercutaneousTherapy,ClinicaNuestraSen?oradel
Rosario,Madrid,Spain
Abstract
Background:InternalJugularVeins(IJVs)aretheprincipleoutflowpathwayforintracranialbloodinclinostatismcondition.
Intheseatedposition,IJVscollapse,whileVertebralVeins(VVs)increasethevenousoutflowandpartiallycompensatethe
venous drainage. Spinal Epidural Veins are an additional drainage pathway in the seated position. Colour- Doppler-
Sonography(CDS)examinationisabletodemonstrateIJVsandVVsoutflowindifferentposturalandrespiratoryconditions.
ThepurposeofthisstudywastoevaluateCDSquantificationofthecerebralvenousoutflow(CVF)inhealthysubjectsand
patientswithmultiplesclerosis(MS).
Methodology/PrincipalFindings:Inagroupof27healthyadults(13femalesand14males;meanage37.8611.2years),
and52patientswithMS(32femalesand20males;meanage42.6612.1years),CVFhasbeenmeasuredinclinostatismand
intheseatedpositionasthesumoftheflowinIJVsandVVs.ThedifferencebetweenCVFinclinostatismandCVFinthe
seatedposition(DCVF)hasbeencorrelatedwithpatients’status(healthyorMS),andanumberofclinicalvariablesinMS
patients. Statistical analysis was performed by Fisher’s exact test, non-parametric Mann-Whitney U test, ANOVA Kruskal-
Wallistest,andcorrentropycoefficient.ThevalueofDCVFwasnegativein59.6%ofpatientswithMSandpositivein96.3%
of healthy subjects. Negative DCVF values were significantly associated with MS (p,0.0001). There was no significant
correlationwithclinical
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