Quantitative ColourDopplerSonography Evaluation of Cerebral Venous Outflow A Comparative Study between Patients with Multiple Sclerosis and Controls 英文参考文献.docVIP

Quantitative ColourDopplerSonography Evaluation of Cerebral Venous Outflow A Comparative Study between Patients with Multiple Sclerosis and Controls 英文参考文献.doc

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Quantitative ColourDopplerSonography Evaluation of Cerebral Venous Outflow A Comparative Study between Patients with Multiple Sclerosis and Controls 英文参考文献

QuantitativeColourDopplerSonographyEvaluationof CerebralVenousOutflow:AComparativeStudybetween PatientswithMultipleSclerosisandControls LuciaMonti1*,ElisabettaMenci1,MonicaUlivelli2,AlfonsoCerase1,SabinaBartalini2,PietroPiu2 ,Nicola Marotti1,SaraLeonini1,PaoloGalluzzi1,DanieleG.Romano1,AlfredoE.Casasco3,CarloVenturi1 1UnitofNeuroimagingandNeurointervention,DepartmentofNeurologicalandSensorialSciences, AziendaOspedaliera Universitaria Senese,Santa MariaalleScotte GeneralHospital,Siena,Italy,2DepartmentofNeurosciences,UniversityofSiena,Siena,Italy,3UnitofEndovascularandPercutaneousTherapy,ClinicaNuestraSen?oradel Rosario,Madrid,Spain Abstract Background:InternalJugularVeins(IJVs)aretheprincipleoutflowpathwayforintracranialbloodinclinostatismcondition. Intheseatedposition,IJVscollapse,whileVertebralVeins(VVs)increasethevenousoutflowandpartiallycompensatethe venous drainage. Spinal Epidural Veins are an additional drainage pathway in the seated position. Colour- Doppler- Sonography(CDS)examinationisabletodemonstrateIJVsandVVsoutflowindifferentposturalandrespiratoryconditions. ThepurposeofthisstudywastoevaluateCDSquantificationofthecerebralvenousoutflow(CVF)inhealthysubjectsand patientswithmultiplesclerosis(MS). Methodology/PrincipalFindings:Inagroupof27healthyadults(13femalesand14males;meanage37.8611.2years), and52patientswithMS(32femalesand20males;meanage42.6612.1years),CVFhasbeenmeasuredinclinostatismand intheseatedpositionasthesumoftheflowinIJVsandVVs.ThedifferencebetweenCVFinclinostatismandCVFinthe seatedposition(DCVF)hasbeencorrelatedwithpatients’status(healthyorMS),andanumberofclinicalvariablesinMS patients. Statistical analysis was performed by Fisher’s exact test, non-parametric Mann-Whitney U test, ANOVA Kruskal- Wallistest,andcorrentropycoefficient.ThevalueofDCVFwasnegativein59.6%ofpatientswithMSandpositivein96.3% of healthy subjects. Negative DCVF values were significantly associated with MS (p,0.0001). There was no significant correlationwithclinical

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