Rare extracranial localization of primary intracranial neoplasm 英文参考文献.docVIP

Diagnostic Pathology BioMedCentral Case Report Open Access Rare extracranial localization of primary intracranial neoplasm Susan Arndt*1, Thorsten Wiech2, Irina Mader3, Antje Aschendorff1 and Wolfgang Maier1 Address: 1Department of Oto-Rhino-Laryngology, Head and Neck Surgery University Medical Center Freiburg, Germany, 2Department of Pathology, University Medical Center Freiburg, Germany and 3Section of Neuroradiology, Neurocenter of the Freiburg University Hospital, Germany Email: Susan Arndt* - arndt@hno.ukl.uni-freiburg.de; Thorsten Wiech - thorsten.wiech@uniklinik-freiburg.de; Irina Mader - irina.mader@uniklinik-freiburg.de; Antje Aschendorff - asch@hno.ukl.uni-freiburg.de; Wolfgang Maier - maier@hno.ukl.uni- freiburg.de * Corresponding author Published: 16 April 2008 Received: 6 March 2008 Accepted: 16 April 2008 Diagnostic Pathology 2008, 3:14 doi:10.1186/1746-1596-3-14 This article is available from: /content/3/1/14 ? 2008 Arndt et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Meningioma, craniopharyngeoma and glioma are mainly intracranial lesions. Nevertheless, in rare cases these entities may occur solely as extracranial lesions that may present as intranasal/ sinusoidal masses, with headaches and nasal obstruction. We present three cases of common intracranial tumors, with purely extracranial extension. The three described cases demonstrate, that preoperative MRI and CT imaging is important for differential diagnosis to exclude intracranial connections of the tumors. A definitive diagnosis requires specialized immunohistochemical examinations. In all cases of intranasal or pharyngeal neoplasm the diagnosis of meningioma, craniopharyngeoma and