Rates of Anti-Tuberculosis Drug Resistance in Kampala-Uganda Are Low and Not Associated with HIV Infection 英文参考文献.docVIP

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Rates of Anti-Tuberculosis Drug Resistance in Kampala-Uganda Are Low and Not Associated with HIV Infection 英文参考文献.doc

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Rates of Anti-Tuberculosis Drug Resistance in Kampala-Uganda Are Low and Not Associated with HIV Infection 英文参考文献

RatesofAnti-TuberculosisDrugResistanceinKampala- UgandaAreLowandNotAssociatedwithHIVInfection DeusLukoye1,3,FrankG.J.Cobelens2,NicholasEzati3,SamuelKirimunda4,FrancisE.Adatu3,JosephK. Lule5,FredNuwaha5,MosesL.Joloba3,4* 1PublicHealthDepartment,KampalaCityCouncil,Kampala,Uganda,2CenterforPoverty-RelatedCommunicableDiseases,AmsterdamInstituteofGlobalHealthand Development, Academic Medical Centre, Amsterdam, The Netherlands, 3National Tuberculosis and Leprosy Programme, Kampala, Uganda, 4Department of Medical Microbiology,SchoolofBiomedicalSciences,MakerereUniversityCollegeofHealthSciences,Kampala,Uganda,5MakerereUniversitySchoolofPublicHealth,Makerere UniversityCollegeofHealthSciences,Kampala,Uganda Abstract Background:Drugresistanceamongtuberculosispatientsinsub-SaharanAfricaisincreasing,possiblyduetoassociation with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosispatientsdiagnosedinKampala,Uganda. Methods/Principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3–2.5) and resistancetoanydrugin57(12.1%,9.3–15.3).Among60previouslytreatedpatientsthiswas7(11.7%,4.8–22.6)and17 (28.3%;17.5–41.4),respectively.Of517patientswithHIVresults,165(31.9%,27.9–36.1)testedpositive.Neithermultidrug (adjusted odds ratio (ORadj) 0.7; 95% CI 0.19–2.6) nor any resistance (ORadj 0.7; 0.43–1.3) was associated with HIV status. Primaryresistancetoanydrugwasmorecommonamongpatientswhohadworkedinhealthcare(ORadj 3.5;1.0–12.0). Conclusion/Significance:Anti-tuberculosisdrugresistanceratesinKampalaarelowandnotassociatedwithHIVinfection, butmaybeassociatedwithexposureduringhealthcare. Citation:LukoyeD,CobelensFGJ,EzatiN,KirimundaS,AdatuFE,etal.(2011)RatesofAnti-TuberculosisDrugResistanceinKampala-UgandaAreLowandNot AssociatedwithHIVInfection.PLoSONE6(1):e16130.doi:10.1371/journal.pone.0016130 Editor:PhilipCampbellHill,UniversityofOtago,NewZealand ReceivedAugust23,2010;AcceptedDe