RD Antigen Based Nanovaccine Imparts Long Term Protection by Inducing Memory Response against Experimental Murine Tuberculosis 英文参考文献.docVIP

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RD Antigen Based Nanovaccine Imparts Long Term Protection by Inducing Memory Response against Experimental Murine Tuberculosis 英文参考文献.doc

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RD Antigen Based Nanovaccine Imparts Long Term Protection by Inducing Memory Response against Experimental Murine Tuberculosis 英文参考文献

RDAntigenBasedNanovaccineImpartsLongTerm ProtectionbyInducingMemoryResponseagainst ExperimentalMurineTuberculosis MairajAhmedAnsari1,SwalehaZubair2,AnjumMahmood3,PushpaGupta4,AijazA.Khan5,UmeshD. Gupta4,AshishArora3,MohammadOwais1* 1InterdisciplinaryBiotechnologyUnit,AligarhMuslimUniversity,Aligarh,UttarPradesh,India,2Women’sCollege,AligarhMuslimUniversity,Aligarh,UttarPradesh,India, 3Molecular and Structural Biology Division, CDRI, Lucknow, Uttar Pradesh, India, 4National JALMA Institute for Leprosy and OMD, Agra, Uttar Pradesh, India, 5DepartmentofAnatomy,JNMC,Aligarh,UttarPradesh,India Abstract Background: The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosisaswellaslackoflastingmemoryresponsesaresomeofthemajorcausesattributedtothenoneffectivenessof Bacille Calmette-Gue’rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protectionagainsttuberculosis. Methods: The immunological responses evoked upon administration of archaeosome based antigen delivery system comprisingTcellantigen,Rv3619c(anESAT-6familyprotein),hasbeenassessedagainstexperimentalmurinetuberculosis inBALB/cmice. Results: Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challengedwithMycobacteriumtuberculosisinfection. Conclusion: The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protectionagainstM.tuberculosisinfection. Citation:AnsariMA,ZubairS,MahmoodA,GuptaP,KhanAA,etal.(2011)RDAntigenBasedNanovaccineImpartsLongTermProtectionbyInducingMemory ResponseagainstExperimentalMurineTuberculosis.PLoSONE6(8):e22889.doi:10.1371/journal.pone.0022889 Editor:LudovicTailleux,InstitutPasteur,France ReceivedFebruary17,2011;AcceptedJune30,2011;PublishedAugust11,2011 Copyright: ? 2011 A