Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles A Novel Non-Radioactive Method 英文参考文献.docVIP

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Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles A Novel Non-Radioactive Method 英文参考文献.doc

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Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles A Novel Non-Radioactive Method 英文参考文献

RapidPharmacokineticandBiodistributionStudiesUsing Cholorotoxin-ConjugatedIronOxideNanoparticles:A NovelNon-RadioactiveMethod MichelleJeung-EunLee1,3,OmidVeiseh4,NarayanBhattarai4,ConroySun4,StaceyJ.Hansen1 ,Sally Ditzler1,SueKnoblaugh2,DonghoonLee5,RichardEllenbogen6,8,MiqinZhang4,6,JamesM.Olson1,3,7,8 * 1ClinicalResearchDivision,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,2AnimalHealthSharedResources,FredHutchinsonCancerResearch Center,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,3NeurobiologyandBehaviorProgram,UniversityofWashington,Seattle,Washington, United States of America, 4Department of Material Science, University of Washington, Seattle, Washington, United States of America, 5Department of Radiology, UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,6DepartmentofNeurosurgery,UniversityofWashington,Seattle,Washington,UnitedStatesof America,7DepartmentofPediatrics,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,8SeattleChildren’sHospital,Seattle,Washington,United StatesofAmerica Abstract Background:Recentadvancesinnanotechnologyhaveledtothedevelopmentofbiocompatiblenanoparticlesforinvivo molecular imaging and targeted therapy. Many nanoparticles have undesirable tissue distribution or unacceptably low serum half-lives. Pharmacokinetic (PK) and biodistribution studies can help inform decisions determining particle size, coatings, or other features early in nanoparticle development. Unfortunately, these studies are rarely done in a timely fashionbecausemanynanotechnologylabslacktheresourcesandexpertisetosynthesizeradioactivenanoparticlesand evaluatetheminmice. Methodology/Principal Findings: To address this problem, we developed an economical, radioactivity-free method for assessingserumhalf-lifeandtissuedistributionofnanoparticlesinmice.Ironoxidenanoparticlescoatedwithchitosanand polyethyleneglycolthatutilizechlorotoxin asatargetingmolecule haveaserumhalf-life of7–8hoursandtheparticle