Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes 英文参考文献.docVIP

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Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes 英文参考文献.doc

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RapidProgressingAlleleHLA-B35PxRestrictedAnti-HIV-1CD8TCellsRecognizeVestigialCTLEpitopes英文参考文献

RapidProgressingAlleleHLA-B35PxRestrictedAnti- HIV-1CD8+TCellsRecognizeVestigialCTLEpitopes ChristianB.Willberg1,KeithE.Garrison1,R.BradJones2,DuncanJ.Meiklejohn1,GeraldSpotts3,TeriJ. Liegler3,MarioA.Ostrowski2,AnnikaC.Karlsson4,5,FrederickM.Hecht3,DouglasF.Nixon1* 1DivisionofExperimentalMedicine,DepartmentofMedicine,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,2Departmentof Immunology, University of Toronto, Toronto, Ontario, Canada, 3Division of HIV/AIDS, Department of Medicine, University of California San Francisco, San Francisco, California,UnitedStatesofAmerica,4DepartmentofMicrobiology,TumorandCellBiology(MTC),KarolinskaInstitutet,Solna,Sweden,5DepartmentofVirology,The SwedishInstituteforInfectiousDiseaseControl,Solna,Sweden Abstract Background:TheHLA-B*35-PxallelehasbeenassociatedwithrapiddiseaseprogressioninHIV-1infection,incontrastto theHLA-B*35-Pyallele. Methodology/Principal Findings: Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA- B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response.Sequencingoftheviralpopulationrevealednoevidenceofvariantvirusinanyoftheindividuals. Conclusions/Significance: This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapidprogressingalleleandthosewiththeHLA-B*35-Pyslowerprogressingallele. Citation: Willberg CB, Garrison KE, Jones RB, Meiklejohn DJ, Spotts G, et al. (2010) Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells RecognizeVestigialCTLEpitopes.PLoSONE5(4):e10249.doi:10.1371/journal.pone.0010249 Editor:DeryaUnutmaz,NewYorkUniversity,UnitedStatesofAmerica ReceivedJanuary30,2010;AcceptedF