Recent Advances in the Synthesis of N-Containing Heteroaromatics via Heterogeneously Transition Metal Catalysed Cross-Coupling Reactions 英文参考文献.docVIP
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Recent Advances in the Synthesis of N-Containing Heteroaromatics via Heterogeneously Transition Metal Catalysed Cross-Coupling Reactions 英文参考文献
Molecules 2011, 16, 5241-5267; doi:10.3390/moleculeOPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
Recent Advances in the Synthesis of N-Containing
Heteroaromatics via Heterogeneously Transition Metal
Catalysed Cross-Coupling Reactions
Laurent Djakovitch *, Nelly Batail and Marie Genelot
Institut de Recherches sur la Catalyse et l’Environnement de Lyon (IRCELYON), Université de Lyon,
CNRS, UMR 5256, 2 avenue Albert Einstein, Villeurbanne F-69626, France
* Author to whom correspondence should be addressed;
E-Mail: Laurent.Djakovitch@ircelyon.univ-lyon1.fr; Tel.: +33-47244-5381; Fax: +33-47244-5399.
Received: 31 May 2011; in revised form: 20 June 2011 / Accepted: 21 June 2011 /
Published: 23 June 2011
Abstract: N-containing heteroaromatics are important substructures found in numerous
natural or synthetic alkaloids. The diversity of the structures encountered, as well as
their biological and pharmaceutical relevance, have motivated research aimed at the
development of new economical, efficient and selective synthetic strategies to access these
compounds. Over more than 100 years of research, this hot topic has resulted in numerous
so-called “classical synthetic methods” that have really contributed to this important area.
However, when the selective synthesis of highly functional heteroaromatics like indoles,
quinolones, indoxyls, etc. is considered these methods remain limited. Recently transition
metal-catalysed (TM-catalysed) procedures for the synthesis of such compounds and further
transformations, have been developed providing increased tolerance toward functional
groups and leading generally to higher reaction yields. Many of these methods have proven
to be the most powerful and are currently applied in target- or diversity-oriented syntheses.
This review article aims at reporting the recent developments devoted to this important
area, focusing on the use of het
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