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Reporting of Systematic Reviews The Challenge of Genetic Association Studies 英文参考文献.doc

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Reporting of Systematic Reviews The Challenge of Genetic Association Studies 英文参考文献

Correspondence Reporting of Systematic Reviews: The Challenge of Genetic Association Studies Julian Little University of Ottawa Ottawa, Ontario, Canada Julian Higgins Institute of Public Health Cambridge, United Kingdom Muin J. Khoury, Julian Little, Julian Higgins, John P. A. Ioannidis, Marta Gwinn John P. A. Ioannidis We applaud PLoS editors for their commitment to publishing high-quality systematic reviews (SRs) [1]. Moher et al. [2] clearly documented the inconsistent quality of reporting of SRs. With more than 2,500 SRs published every year, low-quality or outdated reviews may mislead researchers, providers, and policy makers. The situation could be improved if more evidence-based reporting guidelines were agreed upon, developed, and adhered to. The growing ?eld of genetic associations (GAs) illustrates the urgent need for transparent SRs and meta-analyses. Already, thousands of articles on GAs have been published, and the application of high-throughput genotyping methods may exponentially increase the number of reported associations [3]. Selective reporting of large numbers of false- positive associations could undermine the ?eld and interfere with our ability to translate advances in genomics into clinical practice. University of Ioannina School of Medicine Ioannina, Greece References 1. 2. 3. 4. 5. 6. 7. 8. The PLoS Medicine Editors (2007) Many reviews are systematic but some are more transparent and completely reported than others. PLoS Med 4: e147. doi:10.1371/journal.pmed.0040147 Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG (2007) Epidemiology and reporting characteristics of systematic reviews. PLoS Med 4: e78. doi: 10.1371/journal.pmed.0040078 Khoury MJ, Little J, Gwinn M, Ioannidis JP (2006) On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol. E-pub 20 December 2006. Centers for Disease Control and Prevention (2007) Human Genome Epidemiology Networ