Review of bioinformatics basics applications in biological science and medicine by Buehler Rashidi 英文参考文献.docVIP

BioMedical Engineering OnLine BioMedCentral Book review Open Access Review of bioinformatics basics: applications in biological science and medicine by Buehler Rashidi Aedín Culhane* Address: Dana-Farber Cancer Institute and Harvard School of Public Health, Department of Biostatistics and Computational Biology, 44 Binney Street, Boston, Massachusetts 02115, USA Email: Aedín Culhane* - Aedin@ * Corresponding author Published: 19 June 2006 Received: 26 May 2006 Accepted: 19 June 2006 BioMedical Engineering OnLine 2006, 5:41 doi:10.1186/1475-925X-5-41 This article is available from: /content/5/1/41 ? 2006 Culhane; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Book details information meaningless. This chapter is structured around a description of the web resources provide by the large bioinformatic institutes (NCBI, EBI). This results in a chapter with poor layout and repetition. For example, interpretation of the BLAST E-value statistic is described twice. This layout is unsatisfactory also as it tends to focus on older databases ignoring valuable recent resources. It is a pity that the authors did not direct the reader to the annual Nucleic Acids Research Database and Web Server issues. Major themes central to Bioinformatics such as multiple alignment and phylogenetic tree analysis are poorly addressed. This section briefly mentions ClustalW and directs the reader to the NCBI databases of ortholo- gous genes, Homologene and PFAM. With increasing numbers of complete genomes available, a more compre- hensive introduction to phylogenetic analysis and com- parative genomics would be valuable. Buehler LK, Rashidi HH: Bioinformatics Basics: Applications in