Retinoid-Binding Proteins Similar Protein Architectures Bind Similar Ligands via Completely Different Ways 英文参考文献.docVIP

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Retinoid-Binding Proteins Similar Protein Architectures Bind Similar Ligands via Completely Different Ways 英文参考文献.doc

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Retinoid-Binding Proteins Similar Protein Architectures Bind Similar Ligands via Completely Different Ways 英文参考文献

Retinoid-BindingProteins:SimilarProteinArchitectures BindSimilarLigandsviaCompletelyDifferentWays Yu-RuZhang1,2,Yu-QiZhao1,2,Jing-FeiHuang1,3 * 1StateKeyLaboratoryofGeneticResourcesandEvolution,KunmingInstituteofZoology,ChineseAcademyofSciences,Kunming,Yunnan,China,2GraduateSchoolof ChineseAcademyofSciences,Beijing,China,3KunmingInstituteofZoology-ChineseUniversityofHongkongJointResearchCenterforBio-ResourcesandHumanDisease Mechanisms,Kunming,China Abstract Background:RetinoidsareaclassofcompoundsthatarechemicallyrelatedtovitaminA,whichisanessentialnutrientthat playsakeyroleinvision,cellgrowthanddifferentiation.Invivo,retinoidsmustbindwithspecificproteinstoperformtheir necessary functions. Plasma retinol-binding protein (RBP) and epididymal retinoic acid binding protein (ERABP) carry retinoidsinbodilyfluids,whilecellularretinol-bindingproteins(CRBPs)andcellularretinoicacid-bindingproteins(CRABPs) carryretinoidswithincells.Interestingly,althoughallofthesetransportproteinspossesssimilarstructures,themodesof bindingforthedifferentretinoidligandswiththeircarrierproteinsaredifferent. Methodology/PrincipalFindings:Inthiswork,weanalyzedthevariousretinoidtransportmechanismsusingstructureand sequencecomparisons,bindingsiteanalysesandmoleculardynamicssimulations.Ourresultsshowthatinthesamefamily ofproteinsandsubcellularlocation,theorientationofaretinoidmoleculewithinabindingproteinissame,whereaswhen differentfamiliesofproteinsareconsidered,theorientationoftheboundretinoidiscompletelydifferent.Inaddition,none of the amino acid residues involved in ligand binding is conserved between the transport proteins. However, for each specificbindingprotein,theaminoacidsinvolvedintheligandbindingareconserved.Theresultsofthisstudyallowusto proposeapossibletransportmodelforretinoids. Conclusions/Significance:Ourresultsrevealthedifferencesinthebindingmodesbetweenthedifferentretinoid-binding proteins. Citation:ZhangY-R,ZhaoY-Q,HuangJ-F(2012)Retinoid-BindingProteins:SimilarProteinArchitectu