Retrieval of Missing Spliced Leader in Dinoflagellates 英文参考文献.docVIP

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Retrieval of Missing Spliced Leader in Dinoflagellates 英文参考文献.doc

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Retrieval of Missing Spliced Leader in Dinoflagellates 英文参考文献

RetrievalofMissingSplicedLeaderinDinoflagellates HuanZhang,SenjieLin* DepartmentofMarineSciences,UniversityofConnecticut,Groton,Connecticut,UnitedStatesofAmerica Abstract Splicedleader(SL)trans-splicinghasrecentlybeenshowntobeacommonmRNAprocessingmechanismindinoflagellates, in which ashort (22-nt) sequence, DCCGUAGCCAUUUUGGCUCAAG (D=U,A, or G), is transplanted from the 59-end of a small non-coding RNA (SL RNA) to the 59 end of mRNA molecules. The widespread existence of the mechanism in dinoflagellates has been demonstrated by detection of this SL (DinoSL) in a wide phylogenetic range of dinoflagellates. Furthermore, thepresenceofDinoSLin thetranscripts ofhighlydiversegroups ofnuclear-encodedgeneshasledusto postulatethatSLtrans-splicingisuniversalindinoflagellatenucleargenome.However,someobservationsinconsistentto thispostulationhavebeenreported,exemplifiedbyarecentarticlereportingapparentabsenceofDinoSLinthetranscripts ofsomenuclear-encodedgenesinAmphidiniumcarterae.AbsenceofSLinthesegenetranscriptswouldhaveimportant implicationongeneregulationindinoflagellatesandutilityofDinoSLasauniversaldinoflagellate-specificprimertostudy dinoflagellatetranscriptomics.Inthisstudy,were-examinedtranscriptsofthesegenesandfoundthatallofthemactually containedDinoSL.Therefore,resultstodateareconsistenttoourinitialpostulationthatDinoSLoccursinalldinoflagellate nuclear-encodedmRNAs. Citation:ZhangH,LinS(2009)RetrievalofMissingSplicedLeaderinDinoflagellates.PLoSONE4(1):e4129.doi:10.1371/journal.pone.0004129 Editor:ChristopheHerman,BaylorCollegeofMedicine,UnitedStatesofAmerica ReceivedOctober15,2008;AcceptedDecember4,2008;PublishedJanuary5,2009 Copyright: ? 2009 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisstudyissupportedbytheNSFgrantsEF-0626678.Thefundershadnoroleinstudydesign,dataco