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Resting Network Plasticity Following Brain Injury 英文参考文献
RestingNetworkPlasticityFollowingBrainInjury
ToruNakamura1,FrankG.Hillary2*,BharatB.Biswal1*
1DepartmentofRadiology,UniversityofMedicineandDentistryofNewJersey–NewJerseyMedicalSchool,Newark,NewJersey,UnitedStatesofAmerica,2Department
ofPsychology,PennStateUniversity,UniversityPark,Pennsylvania,UnitedStatesofAmerica
Abstract
Thepurposeofthisstudywastoexamineneuralnetworkpropertiesatseparatetime-pointsduringrecoveryfromtraumatic
braininjury(TBI)usinggraphtheory.Whole-brainanalysesofthetopologicalpropertiesofthefMRIsignalwereconducted
in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties
including a change in the degree distribution, reduced overall strength in connectivity, and increased ‘‘small-worldness’’
from3monthsto6monthspostinjury.Thefindingshereindicatethat,duringrecoveryfrominjury,thestrengthbutnot
thenumberofnetworkconnectionsdiminishes,sothatoverthecourseofrecovery,thenetworkbeginstoapproximate
whatisobservedinhealthyadults.Thesearethefirstdataexaminingfunctionalconnectivityinadisruptedneuralsystem
duringrecovery.
Citation:NakamuraT,HillaryFG,BiswalBB(2009)RestingNetworkPlasticityFollowingBrainInjury.PLoSONE4(12):e8220.doi:10.1371/journal.pone.0008220
Editor:OlafSporns,IndianaUniversity,UnitedStatesofAmerica
ReceivedJuly9,2009;AcceptedNovember6,2009;PublishedDecember14,2009
Copyright: ? 2009 Nakamura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThecurrentworkissupportedbyUSNationalInstitutesofHealthgrant5R01NS049176toB.B.Thefundershadnoroleinstudydesign,datacollection
andanalysis,decisiontopublish,orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist.
*E-mail:fhillary@(FGH);bbiswal@(BBB)
Introduction
are changing after neural disruption. The current study aims
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