Response to the commentary Pooled indices to measure rheumatoid arthritis activity a good reflection of the physicians mind 英文参考文献.docVIP
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Response to the commentary Pooled indices to measure rheumatoid arthritis activity a good reflection of the physicians mind 英文参考文献
Available online /content/8/6/406
Letter
Response to the commentary ‘Pooled indices to measure
rheumatoid arthritis activity: a good reflection of the physician’s
mind’
Bert Vander Cruyssen1, Patrick Durez2, Rene Westhovens3, Nathan Vastesaeger4, Anja Geldhof5
and Filip De Keyser1
1Rheumatology, Ghent University Hospital, Belgium
2Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
3Rheumatology, University Hospitals KULeuven, Leuven, Belgium
4Medical affaires, Schering Plough, Brussels, Belgium
5Medical affaires, Centocor, Leiden, the Netherlands
Corresponding author: Bert Vander Cruyssen, Bert.VanderCruyssen@Ugent.be
Published: 10 October 2006
Arthritis Research Therapy 2006, 8:406 (doi:10.1186/ar2044)
This article is online at /content/8/6/406
? 2006 BioMed Central Ltd
See related commentary by Aletaha, /content/8/1/102, related research article by Vander Cruyssen et al.,
/content/7/5/R1063, and related commentary by van Riel and Fransen, /content/7/5/189
The February issue of Arthritis Research Therapy included
a commentary by Aletaha [1] on a recent report from our
group [2].
A third issue highlighted by Aletaha [1] and by Van Riel and
Fransen [3] is that in our study more than 50% of patients did
not receive a dose increase, even though those patients had
a DAS28 score greater than 3.2, indicating moderate or high
First, Aletaha states that evaluation of the ‘physician’s mind’ is
best performed in a study setting in which the physician is
unaware that their clinical decision is part of the investigation.
It should be noted that the analysis we reported [2] was a
post hoc analysis on a cohort of patients with rheumatoid
arthritis (RA) who began infliximab therapy within the context
of an expanded access programme, and in which infliximab
therapy was provided for free until reimbursement in 2002. In
the initial protocol it was pre-specified that, from week 30
o
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