Research Questions and Priorities for Tuberculosis A Survey of Published Systematic Reviews and Meta-Analyses 英文参考文献.docVIP

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Research Questions and Priorities for Tuberculosis A Survey of Published Systematic Reviews and Meta-Analyses 英文参考文献.doc

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Research Questions and Priorities for Tuberculosis A Survey of Published Systematic Reviews and Meta-Analyses 英文参考文献

ResearchQuestionsandPrioritiesforTuberculosis:A SurveyofPublishedSystematicReviewsandMeta- Analyses IoanaNicolau1,DaphneLing1,LuluTian2,ChristianLienhardt3,MadhukarPai1* 1McGillUniversity,Montreal,Quebec,Canada,2EmoryUniversity,Atlanta,Georgia,UnitedStatesofAmerica,3StopTBPartnership,WorldHealthOrganization,Geneva, Switzerland Abstract Background:Systematicreviewsareincreasinglyinformingpoliciesintuberculosis(TB)careandcontrol.Theymayalsobea sourceofquestionsforfutureresearch.AspartoftheprocessofdevelopingtheInternationalRoadmapforTBResearch,we did a systematic review of published systematic reviews on TB, to identify research priorities that are most frequently suggestedinreviews. Methodology/PrincipalFindings:WesearchedEMBASE,MEDLINE,WebofScience,andtheCochraneLibraryforsystematic reviews and meta-analyses on any aspect of TB published between 2005 and 2010. One reviewer extracted data and a secondreviewerindependentlyextracteddatafromarandomsubsetofincludedstudies.Intotal,137systematicreviews, with141researchquestions,wereincludedinthisreview.WeusedtheUKHealthResearchClassificationSystem(HRCS)to helpusclassifytheresearchquestionsandpriorities.Thethreemostcommonresearchtopicswereintheareaofdetection, screeninganddiagnosisofTB(32.6%),developmentandevaluationoftreatmentsandtherapeuticinterventions(23.4%), and TB aetiology and risk factors (19.9%). The research priorities determined were mainly focused on the discovery and evaluationofbacteriologicalTBtestsanddrug-resistantTBtestsandimmunologicaltests.Otherimportanttopicsoffuture research were genetic susceptibility linked to TB and disease determinants attributed to HIV/TB. Evaluation of drug treatmentsforTB,drug-resistantTBandHIV/TBwerealsofrequentlyproposedresearchtopics. Conclusions:Systematicreviewsareagoodsourceofkeyresearchpriorities.Findingsfromoursurveyhaveinformedthe developmentoftheInternationalRoadmapforTBResearchbytheTBResearchMovement. Citation:NicolauI,LingD,TianL,LienhardtC,PaiM(2012)ResearchQuestio