Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma A case--control study 英文参考文献.docVIP
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Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma A case--control study 英文参考文献
Pronketal.EnvironmentalHealth2013,12:20
/content/12/1/20
RESEARCH
OpenAccess
Residentialproximitytoindustrialcombustion
facilitiesandriskofnon-Hodgkinlymphoma:a
case–controlstudy
AnjoekaPronk1,2,JohnRNuckols3,AnneclaireJDeRoos4,5,MatthewAirola6,JoanneSColt1,JamesRCerhan7,
LindsayMorton1,WendyCozen8,RichardSeverson9,AaronBlair1,DavidCleverly10andMaryHWard1,11*
Abstract
Background:Residencenearmunicipalsolidwasteincinerators,amajorhistoricalsourceofdioxinemissions,has
beenassociatedwithincreasedriskofnon-Hodgkinlymphoma(NHL)inEuropeanstudies.Theaimofourstudy
wastoevaluateresidencenearindustrialcombustionfacilitiesandestimatesofdioxinemissionsinrelationtoNHL
riskintheUnitedStates.
Methods:Weconductedapopulation-basedcase–controlstudyofNHL(1998–2000)infourNationalCancer
Institute-SurveillanceEpidemiologyandEndResultscenters(Detroit,Iowa,LosAngeles,Seattle).Residentialhistories
15yearsbeforediagnosis(similardateforcontrols)werelinkedtoanEnvironmentalProtectionAgencydatabaseof
dioxin-emittingfacilitiesfor969casesand749controls.Weevaluatedproximity(3and5km)to10facilitytypes
thataccountedfor85%ofU.S.emissionsandadistance-weightedaverageemissionindex(AEI[ngtoxic
equivalencyquotient(TEQ)/year]).
Results:Proximitytoanydioxin-emittingfacilitywasnotassociatedwithNHLrisk(3kmOR=1.0,95%CI0.8-1.3).
Riskwaselevatedforresidencenearcementkilns(5kmOR=1.7,95%CI0.8-3.3;3kmOR=3.8,95%CI1.1-14.0)and
reducedforresidencenearmunicipalsolidwasteincinerators(5kmOR=0.5,95%CI0.3-0.9;3kmOR=0.3,95%
CI0.1-1.4).TheAEIwasnotassociatedwithriskofNHLoverall.Riskformarginalzonelymphomawasincreasedfor
thehighestversuslowestquartile(5kmOR=2.6,95%CI1.0-6.8;3kmOR=3.0,95%CI1.1-8.3).
Conclusions:Overall,wefoundnoassociationwithresidentialexposuretodioxinsandNHLrisk.However,findings
forhighemissionsandmarginalzonelymphomaandforspecificfacilitytypesandallNHLprovidesomeevidence
ofanassociationanddeservefuturestudy.
Keywords:Non-Hodgkinlymphoma,Lymphomas,Dioxins,Airpollution,Geographicinformationsystems,
Case–contr
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