Replicative genomics can help Helicobacter fraternity usher in good times 英文参考文献.docVIP

AhmedGutPathogens2010,2:25 /content/2/1/25 EDITORIAL OpenAccess ReplicativegenomicscanhelpHelicobacterfraternity usheringoodtimes NiyazAhmed1,2 Editorial to the H. pylori infection outcome -for example, the Ifwedrawaparallelamongtwooftheage-oldscourges Indianenigma[6]ortheMalaysianenigma[7]. ofhumans,MycobacteriumtuberculosisandHelicobacter H.pylori’scoregenomeisalmostconservedwithclose pylori,wewillfindagreatsuperimpositionofthetwoin to1200genes.However,its‘variome’comprisedmajorly terms of their history, ecology, geographic distribution ofhighlyfluid,plasticityzones(PZs)couldbeofsignifi- and the fact that both the pathogens get fiercely cant research interest because it contains novel genes engaged with host innate defenses and avoid clearance andgenetic elements whosecomposition andstructure due to being highly adapted to their niches [1]. How- varies and evolves in association with the geographic ever,thepatternoftheirchromosomalevolutionisvery descent of the strains and host ecology/physiology. different [2]. Whole genome sequencing revealed that Functional level understanding ofsuchplastic genomic M. tuberculosis pangenome is of a closed type because repertoires could be very significant in understanding ofitslargelybeingconserved[3]andthatofH.pyloriis mechanismsofadaptationsandsurvivalovertimewith- aninfinitelyopenone[4],meaningthatdozensofnew, outbeingclearedbytheinnateimmunesystem.There- undefinedgenesandgeneticelementswillbeidentified fore,thewealthofcomparativegenomicdataemanating with the addition of each new genome to the existing from multiple whole genome sequencing projects will pan-genomeofthelatter.Thisisgoodnewsforsequen- make it possible to systematically decipher functional cing companies who were not happy with loosing the consequences of genomic diversity at population level business opportunities with Mycobacterium research [5]. Such data will also be helpful to understand how comm