Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats A Natural Model of Lentivirus-Induced Renal Disease Changes 英文参考文献.docVIP

Viruses 2012, 4, 1372-1389; doi:10.3390/v4091372 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats: A Natural Model of Lentivirus-Induced Renal Disease Changes Alessandro Poli 1, Natasa Tozon 2, Grazia Guidi 3 and Mauro Pistello 4,* 1 Department of Animal Pathology, Prophylaxis and Food Hygiene, Veterinary Faculty, University of Pisa, Viale delle Piagge 2, Pisa 56124, Italy; E-Mail: apoli@vet.unipi.it 2 Clinic for Small Animal Medicine and Surgery, Veterinary Faculty, University of Ljubljana, Gerbi?eva 60, Ljubljana 1000, Slovenia; E-Mail: Natasa.Tozon@vf.uni-lj.si 3 Department of Veterinary Clinic, Veterinary Faculty, University of Pisa, Via Livornese, San Piero a Grado, Pisa 56122, Italy; E-Mail: guidi@vet.unipi.it 4 Department of Experimental Pathology, University of Pisa, Via S. Zeno, 35/39, Pisa 56127, Italy * Author to whom correspondence should be addressed; E-Mail: mauro.pistello@med.unipi.it; Tel.: +39-050-221-3781; Fax: +39-050-221-3524. Received: 18 July 2012; in revised form: 15 August 2012 / Accepted: 16 August 2012 / Published: 27 August 2012 Abstract: Human immunodeficiency virus (HIV) is associated with several renal syndromes including acute and chronic renal failures, but the underlying pathogenic mechanisms are unclear. HIV and feline immunodeficiency virus (FIV) share numerous biological and pathological features, including renal alterations. We investigated and compared the morphological changes of renal tissue of 51 experimentally and 21 naturally infected cats. Compared to the latter, the experimentally infected cats exhibited some mesangial widening and glomerulonephritis, milder proteinuria, and lower tubular and interstitial alterations. The numbers of giant protein tubular casts and tubular microcysts were also lower. In contrast, diffuse interstitial infiltr