Responses of hyperthermophilic crenarchaea to UV irradiation 英文参考文献.docVIP

Open Access Re rch 2007G?tzetVoal.lumesea8, Issue 10, Article R220 Responses of hyperthermophilic crenarchaea to UV irradiation Dorothee G?tz*, Sonia Paytubi?, Stacey Munro?, Magnus Lundgren?, Rolf Bernander? and Malcolm F White? Addresses: *Aquapharm Bio-Discoveries, European Centre for Marine Biotechnology, Dunbeg, Oban PA37 1QA, UK. ?Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK. ?Department of Molecular Evolution, Uppsala University, Norbyv?gen 18C, SE-752 36, Uppsala, Sweden. Correspondence: Malcolm F White. Email: mfw2@st-and.ac.uk Published: 11 October 2007 Received: 29 March 2007 Revised: 9 August 2007 Accepted: 11 October 2007 Genome Biology 2007, 8:R220 (doi:10.1186/gb-2007-8-10-r220) The electronic version of this article is the complete one and can be found online at /2007/8/10/R220 ? 2007 G?tz et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ArchaealcapldaTrhiuest,responseashnoscwriinpgtitooancUVallearesponser responstoe tUVo DirradiationNA damagewasbutanalyzedno increainsetwoin threlatede exprecrenarchaea,ssion of DNASulfolobusrepair gensolfataricuses./p and Sulfolobus acido- Abstract Background: DNA damage leads to cellular responses that include the increased expression of DNA repair genes, repression of DNA replication and alterations in cellular metabolism. Archaeal information processing pathways resemble those in eukaryotes, but archaeal damage response pathways remain poorly understood. Results: We analyzed the transcriptional response to UV irradiation in two related crenarchaea, Sulfolobus solfataricus and Sulfolobus acidocaldarius. Sulfolobus species encounter high levels of DNA damage in nature, as they inhabit