Residential Dampness and Molds and the Risk of Developing Asthma A Systematic Review and Meta-Analysis 英文参考文献.docVIP

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Residential Dampness and Molds and the Risk of Developing Asthma A Systematic Review and Meta-Analysis 英文参考文献.doc

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Residential Dampness and Molds and the Risk of Developing Asthma A Systematic Review and Meta-Analysis 英文参考文献

ResidentialDampnessandMoldsandtheRiskof DevelopingAsthma:ASystematicReviewandMeta- Analysis ReginaldQuansah1,MarittaS.Jaakkola1,2,TimoT.Hugg1,3,SirpaA.M.Heikkinen1,2,JouniJ. K.Jaakkola1,3 * 1CenterforEnvironmentalandRespiratoryHealthResearch,UniversityofOulu,Oulu,Finland,2RespiratoryMedicineUnit,InstituteofClinicalMedicine,Universityof OuluandOuluUniversityHospital,Oulu,Finland,3InstituteofHealthSciences,UniversityofOulu,Oulu,Finland Abstract Context: Studies from different geographical regions have assessed the relations between indoor dampness and mold problemsandtheriskofasthma,buttheevidencehasbeeninconclusive. Objective:Toassesstherelationsbetweenindicatorsofindoordampnessandmoldproblemsandtheriskofdeveloping newasthma,andtoinvestigatewhethersuchrelationsdifferaccordingtothetypeofexposure. Datasources:AsystematicliteraturesearchofPubMeddatabasefrom1990throughMarch2012andthereferencelistsof recentreviewsandofrelevantarticlesidentifiedinoursearch. Studyselection:Cohort/longitudinalandincidentcase-controlstudiesassessingtherelationbetweenmold/dampnessand newasthmawereincluded. Data extraction: Three authors independently evaluated eligible articles and extracted relevant information using a structuredform. Synthesis:Sixteenstudieswereincluded:11cohortand5incidentcase-controlstudies.Thesummaryeffectestimates(EE) based onthehighestandlowestestimates fortherelationbetween anyexposureandonsetofasthma were1.50(95% confidence interval [CI] 1.25–1.80, random-effects model, Q-statistic 38.74 (16), P=0.001) and 1.31 (95% CI 1.09–1.58, random-effects model, Q-statistic 40.08 (16), P=0.000), respectively. The summary effect estimates were significantly elevatedfordampness(fixed-effectsmodel:EE1.33,95%CI1.12–1.56,Q-statistic8.22(9),P=0.413),visiblemold(random- effectsmodel;EE1.29,95%CI1.04–1.60,30.30(12),P=0.001),andmoldodor(random-effectsmodel;EE1.73,95%CI1.19– 2.50, Q-statistics 14.85 (8), P=0.038), but not for water damage (fixed-effects model; EE 1.12, 95% CI 0.98