Review of Stochastic Modelling for Systems Biology by Darren Wilkinson 英文参考文献.docVIP

BioMedical Engineering OnLine BioMedCentral Book review Open Access Review of Stochastic Modelling for Systems Biology by Darren Wilkinson Eric Bullinger* Address: Hamilton Institute, National University of Ireland, Maynooth, Co. Kildare, Ireland Email: Eric Bullinger* - eric.bullinger@nuim.ie * Corresponding author Published: 13 December 2006 Received: 18 November 2006 Accepted: 13 December 2006 BioMedical Engineering OnLine 2006, 5:64 doi:10.1186/1475-925X-5-64 This article is available from: /content/5/1/64 ? 2006 Bullinger; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Stochastic Modelling for Systems Biology by Darren Wilkinson introduces the peculiarities of stochastic modelling in biology. This book is particularly suited to as a textbook or for self-study, and for readers with a theoretical background. Book detail Wilkinson Darren: Stochastic Modelling for Systems Biology Boca Raton, FL, USA: Chapman Hall/CRC. 254 pages, ISBN 1-58488-540-8, USD 79.95. the uniform, Poisson or gamma distributions. Of particu- lar importance in stochastic modelling is the exponential distribution, which is often used to model the times between consecutive reaction. The book lists several statis- tic results with proofs of why such a distribution makes sense. A key step in numerical solvers of stochastic models is the calculation of exponentially distributed numbers. This is discussed in Chapter 4 in combination with an introduction to R, a language and environment for statis- tical computing and graphics [4]. Chapter 5 discusses dis- crete and continuous-time Markov processes. Chapter 6 finally presents numerical solutions of biochemical reac- tion models, from ordinar