Rheumatoid arthritis GWAS or TMI 英文参考文献.docVIP

Minireview Rheumatoid arthritis: GWAS or TMI? Bruce N Cronstein Address: New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Email: cronsb01@ certainly exemplify a collaborative approach backed up by considerable technology and advanced data analysis. Investigators at 12 different academic institutions and one Abstract Genome-wide association studies are the most comprehensive and straightforward approach to teasing out the identity of company in three different countries are listed as coauthors on the work, and state-of-the-art technology was used to analyze the frequency of 278,502 SNPs in 2,418 North American patients and 4,504 North American controls of European origin. The total number of patients was divided into discovery and replication cohorts to add rigor to the analysis, and the statistical analysis of the results was genetic polymorphisms associated with any given disease or characteristic. With the availability of DNA banks from large cohorts of ethnically matched patients and healthy individuals it is now possible to define even marginal genetic associations between genetic polymorphisms and diseases. As increasing numbers of these studies are carried out and as associations with smaller and smaller risks are identified, there is the growing concern that the findings will be of increasingly marginal value. Thus, the glut of new genetic associations is rapidly over- whelming our interest in the results, a situation that could be highly stringent and used standard computerized approaches. In addition to making the new observation on association of a SNP in REL with RA, the study also revealed associations with the genes encoding cytotoxic T-lymphocyte antigen 4 (CTLA4) and B-cell lymphocyte kinase (BLK) and confirmed the association of other genetic