Rift Valley Fever Virus Seroprevalence in Human Rural Populations of Gabon 英文参考文献.docVIP

RiftValleyFeverVirusSeroprevalenceinHumanRural PopulationsofGabon XavierPourrut1,2.*,Dieudonne′ Nkoghe′2.*,MarcSouris3,ChristophePaupy2,4,JanuszPaweska5 ,Cindy Padilla2,GhislainMoussavou2,EricM.Leroy1,2 1Institut deRecherche pourleDe′veloppement,UMR190,Marseille,France,2Centre International deRecherchesMe′dicales, BP769,Franceville,Gabon, 3Institut de RecherchepourleDe′veloppement,UMR190,MahidolUniversity,NakhonPathom,Tha?¨land,4InstitutdeRecherchepourleDe′veloppement,UR16,Montpellier,France, 5SpecialPathogensUnit,NationalInstituteforCommunicableDiseases,Johannesburg,SouthAfrica Abstract Background:RiftValleyfever(RVF)isamosquito-borneviralzoonosiscausedbyaphlebovirusandtransmittedbyAedes mosquitoes. Humans can also be infected through direct contact with blood (aerosols) or tissues (placenta, stillborn) of infectedanimals.Althoughsevereclinicalcasescanbeobserved,infectionwithRVFvirus(RVFV)inhumansis,inmostcases, asymptomaticorcausesafebrileillnesswithoutserioussymptoms.InsmallruminantsRVFVmainlycausesabortionand neonatal death. The distribution of RVFV has been welldocumented in manyAfrican countries, particularly in thenorth (Egypt,Sudan),east(Kenya,Tanzania,Somalia),west(Senegal,Mauritania)andsouth(SouthAfrica),butalsointheIndian Ocean(Madagascar,Mayotte)andtheArabianPeninsula.Incontrast,theprevalenceofRVFVhasrarelybeeninvestigatedin centralAfricancountries. Methodology/Principal Findings: We therefore conducted a large serological survey of rural populations in Gabon, involving 4,323 individuals from 212 randomly selected villages (10.3% of all Gabonese villages). RVFV-specific IgG was found in a total of 145 individuals (3.3%) suggesting the wide circulation of Rift Valley fever virus in Gabon. The seroprevalencewassignificantlyhigherinthelakesregionthaninforestandsavannaszones,withrespectiveratesof8.3%, 2.9%and2.2%.Inthelakesregion,RVFV-specificIgGwassignificantlymoreprevalentinmalesthaninfemales(respectively 12.8%and3.8%)andtheseroprevalenceincreased