Risk Factors for Campylobacteriosis of Chicken, Ruminant, and Environmental Origin A Combined Case-Control and Source Attribution Analysis 英文参考文献.docVIP

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Risk Factors for Campylobacteriosis of Chicken, Ruminant, and Environmental Origin A Combined Case-Control and Source Attribution Analysis 英文参考文献.doc

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Risk Factors for Campylobacteriosis of Chicken, Ruminant, and Environmental Origin A Combined Case-Control and Source Attribution Analysis 英文参考文献

RiskFactorsforCampylobacteriosisofChicken, Ruminant,andEnvironmentalOrigin:ACombinedCase- ControlandSourceAttributionAnalysis LapoMughiniGras1,2,3*.,JoostH.Smid2.,JaapA.Wagenaar4,5,6,AlbertG.deBoer4,ArieH.Havelaar2,7, IngridH.M.Friesema2,NigelP.French8,LucaBusani1,WilfridvanPelt2 1Istituto Superiore di Sanita`, DepartmentofVeterinary Public Health andFood Safety,Rome, Italy, 2NationalInstitute ofPublicHealth and theEnvironment(RIVM), CentreforInfectiousDiseaseControl,Bilthoven,TheNetherlands,3BolognaUniversity,DepartmentofVeterinaryMedicalSciences,Bologna,Italy,4CentralVeterinary InstituteofWageningenUR,DepartmentofBacteriologyandTSEs,Lelystad,TheNetherlands,5UtrechtUniversity,DepartmentofInfectiousDiseasesandImmunology, Utrecht, The Netherlands, 6World Health Organization Collaborating Centre for Reference and Research on Campylobacter/OIE Reference Laboratory for Campylobacteriosis, Lelystad/Utrecht, The Netherlands, 7Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands, 8Massey University, InfectiousDiseaseResearchCentre,PalmerstonNorth,NewZealand Abstract Background:Campylobacteriosiscontributesstronglytothediseaseburdenoffood-bornepathogens.Case-controlstudies are limited in attributing human infections to the different reservoirs because they can only trace back to the points of exposure,whichmaynotpointtotheoriginalreservoirsbecauseofcross-contamination.HumanCampylobacterinfections can be attributed to specific reservoirs by estimating the extent of subtype sharing between strains from humans and reservoirsusingmultilocussequencetyping(MLST). Methodology/Principal Findings: We investigated risk factors for human campylobacteriosis caused by Campylobacter strainsattributedtodifferentreservoirs.Sequencetypes(STs)weredeterminedfor696C.jejuniand41C.colistrainsfrom endemichumancasesincludedinacase-controlstudy.Theasymmetricislandmodel,apopulationgeneticsapproachfor modeling Campylobacter evolution and transmission, attributed the