Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression 英文参考文献.docVIP

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Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression 英文参考文献.doc

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Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression 英文参考文献

BMC Physiology BioMedCentral Research article Open Access Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression Hideo Makimura1,2, Tooru M Mizuno1,2, Fumiko Isoda1,2, Joe Beasley2,3, Jeffrey H Silverstein2,3 and Charles V Mobbs*1,2 Address: 1Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA 10029, 2Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA 10029 and 3Department of Anesthesiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA 10029 Email: Hideo Makimura - Hideo.Makimura@; Tooru M Mizuno - Tooru.Mizuno@; Fumiko Isoda - Fumiko.Isoda@; Joe Beasley - Joseph.Beasley@; Jeffrey H Silverstein - Jeff.Silverstein@; Charles V Mobbs* - Charles.Mobbs@ * Corresponding author Published: 09 July 2003 Received: 29 January 2003 Accepted: 09 July 2003 BMC Physiology 2003, 3:5 This article is available from: /1472-6793/3/5 ? 2003 Makimura et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Fasting and diabetes are characterized by elevated glucocorticoids and reduced insulin, leptin, elevated hypothalamic AGRP and NPY mRNA, and reduced hypothalamic POMC mRNA. Although leptin replacement can reverse changes in hypothalamic gene expression associated with fasting and diabetes, leptin also normalizes corticosterone; therefore the extent to which the elevated corticosterone contributes to the regulation of hypothalamic gene expression in fasting and diabetes remains unclear. To address if elevated corticosterone is necessary for hypothalamic responses to fast