Risk Factors for Death among Children Less than 5 Years Old Hospitalized with Diarrhea in Rural Western Kenya, 2005–2007 A Cohort Study 英文参考文献.docVIP

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Risk Factors for Death among Children Less than 5 Years Old Hospitalized with Diarrhea in Rural Western Kenya, 2005–2007 A Cohort Study 英文参考文献.doc

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Risk Factors for Death among Children Less than 5 Years Old Hospitalized with Diarrhea in Rural Western Kenya, 2005–2007 A Cohort Study 英文参考文献

RiskFactorsforDeathamongChildrenLessthan5Years OldHospitalizedwithDiarrheainRuralWesternKenya, 2005–2007:ACohortStudy CiaraE.O’Reilly1*,PeterJaron2,BenjaminOchieng2,AmekNyaguara2,JacquelineE.Tate3, MicheleB.Parsons1,CherylA.Bopp1,KaraA.Williams3,JanVinje′3,ElizabethBlanton1, KathleenA.Wannemuehler1,JohnVulule4,KaylaF.Laserson2,5,RobertF.Breiman2,5,DanielR.Feikin2,5 Marc-AlainWiddowson3,EricMintz1 , 1Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention,Atlanta,Georgia,UnitedStatesofAmerica,2KenyaMedicalResearchInstitute/CentersforDiseaseControlandPrevention,Kisumu,Kenya,3DivisionofViral Diseases,NationalCenterforImmunization,andRespiratoryDiseases,CentersforDiseaseControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica,4Centrefor GlobalHealthResearch,KenyaMedicalResearchInstitute,Kisumu,Kenya,5CenterforGlobalHealth,CentersforDiseaseControlandPrevention,Atlanta,Georgia,United StatesofAmerica Abstract Background:Diarrheaisaleadingcauseofchildhoodmorbidityandmortalityinsub-SaharanAfrica.Dataonriskfactorsfor mortality are limited. We conducted hospital-based surveillance tocharacterize theetiology of diarrhea andidentify risk factorsfordeathamongchildrenhospitalizedwithdiarrheainruralwesternKenya. MethodsandFindings:Weenrolledallchildren,5yearsold,hospitalizedwithdiarrhea($3loosestoolsin24hours)at two district hospitals in Nyanza Province, western Kenya. Clinical and demographic information was collected. Stool specimensweretestedforbacterialandviralpathogens.Bivariateandmultivariablelogisticregressionanalyseswerecarried outtoidentifyriskfactorsfordeath.FromMay23,2005toMay22,2007,1,146children,5yearsoldwereenrolled;107 (9%)childrendiedduringhospitalization.NontyphoidalSalmonellawereidentifiedin10%(118),Campylobacterin5%(57), andShigellain4%(42)of1,137stoolsamples;rotaviruswasdetectedin19%(196)of1,021stoolsamples.Amongstools fromchildrenwhodied,nontyphoid