Role of the Dopaminergic System in the Acquisition, Expression and Reinstatement of MDMA-Induced Conditioned Place Preference in Adolescent Mice 英文参考文献.docVIP

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Role of the Dopaminergic System in the Acquisition, Expression and Reinstatement of MDMA-Induced Conditioned Place Preference in Adolescent Mice 英文参考文献.doc

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Role of the Dopaminergic System in the Acquisition, Expression and Reinstatement of MDMA-Induced Conditioned Place Preference in Adolescent Mice 英文参考文献

RoleoftheDopaminergicSystemintheAcquisition, ExpressionandReinstatementofMDMA-Induced ConditionedPlacePreferenceinAdolescentMice AntonioVidal-Infer,Concepcio′nRoger-Sa′nchez,ManuelDaza-Losada,Mar?′aA.Aguilar,Jose′ Min?arro, MartaRodr?′guez-Arias* UnitofResearchonPsychobiologyofDrugDependence,UniversityofValencia,Valencia,Spain Abstract Background: The rewarding effects of 3,4-methylenedioxy-metamphetamine (MDMA) have been demonstrated in conditionedplacepreference(CPP)procedures,buttheinvolvementofthedopaminergicsysteminMDMA-inducedCPP andreinstatementispoorlyunderstood. Methodology/PrincipalFindings:Inthisstudy,theeffectsoftheDAD1antagonistSCH23390(0.125and0.250mg/kg),the DAD2antagonistHaloperidol(0.1and0.2mg/kg),theD2antagonistRaclopride(0.3and0.6mg/kg)andthedopamine release inhibitor CGS 10746B (3 and 10mg/kg) on the acquisition, expression and reinstatement of a CPP induced by 10mg/kgofMDMAwereevaluatedinadolescentmice.Asexpected,MDMAsignificantlyincreasedthetimespentinthe drug-paired compartment during the post-conditioning (Post-C) test, and a priming dose of 5mg/kg reinstated the extinguished preference. The higher doses of Haloperidol, Raclopride and CGS 10746B and both doses of SCH 23390 blockedacquisitionoftheMDMA-inducedCPP.However,onlyHaloperidolblockedexpressionoftheCPP.Reinstatementof theextinguishedpreferencewasnotaffectedbyanyofthedrugsstudied.Analysisofbrainmonoaminesrevealedthatthe blockade of CPP acquisition was accompanied by an increase in DA concentration in the striatum, with a concomitant decrease in DOPAC and HVA levels. Administration of haloperidol during the Post-C test produced increases in striatal serotonin,DOPACandHVAconcentrations.InmicetreatedwiththehigherdosesofhaloperidolandCGSanincreasein SERTconcentrationinthestriatumwasdetectedduringacquisitionoftheCPP,butnochangesinDATwereobserved. Conclusions/Significance:Theseresultsdemonstratethat,inadolescentmice,thedopaminergicsystemisinvolvedinthe acquisitionandexpressionofMDMA-ind