RosettaRemodel A Generalized Framework for Flexible Backbone Protein Design 英文参考文献.docVIP

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RosettaRemodel A Generalized Framework for Flexible Backbone Protein Design 英文参考文献.doc

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RosettaRemodel A Generalized Framework for Flexible Backbone Protein Design 英文参考文献

RosettaRemodel:AGeneralizedFrameworkforFlexible BackboneProteinDesign Po-SsuHuang1,Yih-EnAndrewBan1¤a,FlorianRichter1,2,IngemarAndre3,RobertVernon4,WilliamR. Schief1*¤b,DavidBaker1,5* 1DepartmentofBiochemistry,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,2InterdisciplinaryPrograminBiomolecularStructureandDesign, UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,3DepartmentofBiochemistryandStructuralBiology,LundUniversity,Lund,Sweden,4Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada, 5Howard Hughes Medical Institute, University of Washington, Seattle, Washington,UnitedStatesofAmerica Abstract WedescribeRosettaRemodel,ageneralizedframeworkforflexibleproteindesignthatprovidesaversatileandconvenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the constructionandelaborationofcustomizedprotocolsforawiderangeofdesignproblemsrangingfromloopinsertionand deletion,disulfideengineering,domainassembly,loopremodeling,motifgrafting,symmetricalunits,todenovostructure modeling. Citation:HuangP-S,BanY-EA,RichterF,AndreI,VernonR,etal.(2011)RosettaRemodel:AGeneralizedFrameworkforFlexibleBackboneProteinDesign.PLoS ONE6(8):e24109.doi:10.1371/journal.pone.0024109 Editor:VladimirN.Uversky,UniversityofSouthFloridaCollegeofMedicine,UnitedStatesofAmerica ReceivedMay16,2011;AcceptedJuly29,2011;PublishedAugust31,2011 Copyright: ? 2011 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: Funding was provided by International AIDS Vaccine Initiative Neutralizing Antibody Consortium () and the Howard Hughes Medical Institute().Thefundershadnoroleinst