Rotavirus Antigenemia in Children Is Associated with Viremia 英文参考文献.docVIP

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Rotavirus Antigenemia in Children Is Associated with Viremia 英文参考文献.doc

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Rotavirus Antigenemia in Children Is Associated with Viremia 英文参考文献

o PL SMEDICINE RotavirusAntigenemiainChildren IsAssociatedwithViremia Sarah E.Blutt1,2,David O.Matson3,Sue E.Crawford1,Mary Allen Staat4,Parvin Azimi5,Berkeley L.Bennett1, Pedro A.Piedra1,Margaret E.Conner1,2* 1DepartmentofMolecularVirologyandMicrobiology,BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica,2MichaelE.DebakeyVeteransAffairsMedical Center,Houston,Texas,UnitedStatesofAmerica,3CenterforPediatricResearch,Norfolk,Virginia,UnitedStatesofAmerica,4CincinnatiChildren’sHospitalMedicalCenter, Cincinnati,Ohio,UnitedStatesofAmerica,5Children’sHospitalofOakland,Oakland,California,UnitedStatesofAmerica Funding:Thisworkwassupported byNationalInstitutesofHealth(NIH) AI10604,NIHAI24998,NIH ABSTRACT DK030144,theOfficeofResearch andDevelopment,MedicalResearch Service,DepartmentofVeterans Affairs,NIHAI145871,theGulfCoast DigestiveDiseaseCenter(NIH DK56338),theUnitedStatesPublic HealthService(N01-AI452252), GlaserPediatricResearchNetwork FellowshipAward,NIHN01-AI30039, aninterinstitutionalgrantfrom Wyeth-LederleVaccinesand Background Antigenemia is commonly detected in rotavirus-infected children. Although rotavirus RNA has been detected in serum, definitive proof of rotavirus viremia has not been shown. We aimed to analyze a defined patient population to determine if infectious virus could be detectedinserafromchildrenwithrotavirusantigenemia. MethodsandFindings Pediatrics,andbyNIHN01-AI45252. Thefundershadnoroleinstudy design,datacollectionandanalysis, decisiontopublish,orpreparation ofthemanuscript. Serum samples obtained upon hospitalization from children with gastroenteritis (57 stool rotavirus-positiveand41rotavirus-negative),childrenwithdiagnosedbronchiolitisofknown(n ?58)orunknown(n?17)viraletiology,childrenwithnoninfectious,nonchronicconditions(n ?17),andhealthyadults(n?28)weretestedforrotavirusantigenbyenzymeimmunoassay (EIA). Results of serum antigen testing were assessed for association with clinical and immunologicalattributesofthechildren.Rotavi