Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial 英文参考文献.docVIP

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Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial 英文参考文献.doc

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Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial 英文参考文献

Available online /content/11/4/R85 Research Open Access Vol 11 No 4 Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial Yoram Kluger1, Bruno Riou2, Rolf Rossaint3, Sandro B Rizoli4, Kenneth David Boffard5, Philip Iau Tsau Choong6, Brian Warren7 and Michael Tillinger8 1Department of Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel 2Departments of Emergency Medicine and Surgery and Anesthesiology and Critical Care, H?pital Pitié Salpêtrière, Assistance Publique-H?pitaux de Paris, Université Pierre et Marie Curie-Paris, Paris, France 3Institute for Anesthesiology, University Clinics, Aachen, Germany 4Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada 5Department of Surgery, Johannesburg Hospital, Johannesburg, South Africa 6National University Hospital, Singapore 7Department of Surgery, University of Stellenbosch, Tygerberg, South Africa 8Novo Nordisk A/S, Bagsv?rd, Denmark Corresponding author: Yoram Kluger, y_kluger@.il Received: 30 May 2007 Revisions requested: 24 Jul 2007 Accepted: 8 Aug 2007 Published: 8 Aug 2007 Critical Care 2007, 11:R85 (doi:10.1186/cc6092) This article is online at: /content/11/4/R85 ? 2007 Kluger et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Trauma is a leading cause of mortality and morbidity, with traumatic brain injury (TBI) and uncontrolled hemorrhage responsible for the majority of these deaths. Recombinant activated factor VIIa (rFVIIa) is being investigated as an adjunctive hemostatic treatment for bleeding refractory to conventional replacement ther