Sakshat Labs Indias Virtual Proteomics Initiative 英文参考文献.docVIP

CommunityPage SakshatLabs:India’sVirtualProteomicsInitiative SandipanRay1,NicoleR.Koshy1,ShyamDiwakar2,BipinNair2,SanjeevaSrivastava1* 1WadhwaniResearchCenterforBiosciencesandBioengineering,DepartmentofBiosciencesandBioengineering,IndianInstituteofTechnologyBombay,Powai,Mumbai, India,2AmritaSchoolofBiotechnology,AmritaVishwaVidyapeetham,Amritapuri,Kollam,Kerala,India Introduction Box1.WhyProteomics? Thanks to the radical progress of Proteomics is one of the most flourishing areas of modern biotechnology research.Thetermproteomedescribestheproteincomplementexpressedbya genome, while proteomics is the study of the entire compendium of proteins encoded by a genome for their expression, localization, interaction, and post- translational modifications. Over the last two decades development of several promising high-throughput proteomic technologies caused a phenomenal revolution in proteomics research and as a result this emerging platform has propelled its growth in multiple disciplines of life sciences [14,15]. Direct involvement of proteins in most of the biological functions and a strong correlationofproteinswithdiseasedconditionsresultintopromising‘‘bed-side’’ applications of clinical proteomics for early detection, rational therapeutic targeting,andpatient-tailoredtherapy[16,17].Realizingtheimmenseimpactof proteomics on clinical and industrial research, universities and colleges have started integrating basic and applied proteomics as a part of their course curriculums to keep the students aware of the basic principles of different commonlyemployedproteomicstechnologiesandprovidehands-ontrainingfor some of the instruments. Although proteomics has been a prominent part of biomedicalresearchforthelastdecadeorsoandhasbecomeanimportantpart of biotechnology course work, establishment of several high-throughput technological facilities required for conducting proteomics courses in academic settings remains challenging because of the shrinking educational budgets