S-Phase Favours Notch Cell Responsiveness in the Drosophila Bristle Lineage 英文参考文献.docVIP

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S-Phase Favours Notch Cell Responsiveness in the Drosophila Bristle Lineage 英文参考文献.doc

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S-Phase Favours Notch Cell Responsiveness in the Drosophila Bristle Lineage 英文参考文献

S-PhaseFavoursNotchCellResponsivenessinthe DrosophilaBristleLineage SylvieRemaud1,2,Agne`sAudibert1,2,MichelGho1,2 * 1Universite′ PierreetMarieCurie,UMR7622,Paris,France,2CNRS,UMR7622,Paris,France Abstract We have studied cell sensitivity to Notch pathway signalling throughout the cell cycle. As model system, we used the Drosophila bristle lineage where at each division N plays a crucial role in fate determination. Using in vivo imaging, we followedthislineageandactivatedtheN-pathwayatdifferentmomentsofthesecondaryprecursorcellcycle.Weshowthat cells are more susceptible to respond to N-signalling during the S-phase. Thus, the period of heightened sensitivity coincidedwiththeperiodoftheS-phase.Moreimportantly,modificationsofS-phasetemporalityinducedcorresponding changesintheperiodofthecell’sreactivitytoN-activation.Moreover,S-phaseabolitionwascorrelatedwithadecreasein the expression of tramtrack, a downstream N-target gene. Finally, N cell responsiveness was modified after changes in chromatin packaging. We suggest that high-order chromatin structures associated with the S-phase create favourable conditionsthatincreasetheefficiencyofthetranscriptionalmachinerywithrespecttoN-targetgenes. Citation:RemaudS,AudibertA,GhoM(2008)S-PhaseFavoursNotchCellResponsivenessintheDrosophilaBristleLineage.PLoSONE3(11):e3646.doi:10.1371/ journal.pone.0003646 Editor:MikhailV.Blagosklonny,OrdwayResearchInstitute,UnitedStatesofAmerica ReceivedSeptember1,2008;AcceptedOctober15,2008;PublishedNovember5,2008 Copyright: ? 2008 Sylvie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ARC(grant3291),ANR(grant05-BLAN-0133),CNRS,UPMC,FRMtoSR. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:Michel.Gho@snv.jussieu.fr Introduction seem to be limited to the asymmetric segregation of