S100B Protein, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in Human Milk 英文参考文献.docVIP

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S100B Protein, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in Human Milk 英文参考文献.doc

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S100B Protein, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in Human Milk 英文参考文献

S100BProtein,Brain-DerivedNeurotrophicFactor,and GlialCellLine-DerivedNeurotrophicFactorinHuman Milk RuisongLi1,WeiXia2,ZhihongZhang1,KunWu1* 1DepartmentofNutritionandFoodHygiene,SchoolofPublicHealth,HarbinMedicalUniversity,Harbin,China,2DepartmentofChildrenHealthandHygiene,Schoolof PublicHealth,HarbinMedicalUniversity,Harbin,China Abstract Background: Human milk contains a wide variety of nutrients that contribute to the fulfillment of its functions, which include the regulation of newborn development. However, few studies have investigated the concentrations of S100B protein,brain-derivedneurotrophicfactor(BDNF),andglialcellline-derivedneurotrophicfactor(GDNF)inhumanmilk.The associationsoftheconcentrationsofS100Bprotein,BDNF,andGDNFwithmaternalfactorsarenotwellexplored. Methodology/PrincipalFindings:ToinvestigatetheconcentrationsofS100Bprotein,BDNF,andGDNFinhumanmilkand characterizethematernalfactorsassociatedwiththeirlevelsinhumanmilk,humanmilksampleswerecollectedatdays3, 10,30,and90afterparturition.LevelsofS100Bprotein,BDNF,andGDNF,andtheirmRNAsinthesamplesweredetected. Then,theseconcentrationswerecomparedwithlactationandothermaternalfactors.S100Bproteinlevelsinhumanmilk samples collected at 3, 10, 30, and 90 d after parturition were 1249.796398.10, 1345.056539.16, 1481.836573.30, and 1414.396621.31ng/L,respectively.Ontheotherhand,theBDNFconcentrationsinhumanmilksampleswere10.9964.55, 13.0165.88, 13.3566.43, and 2.8365.47mg/L, while those of GDNF were 10.9061.65, 11.3861., 11.2963.10, and 11.4062.21g/Lforthesametimeperiods.Maternalpost-pregnancybodymassindexwaspositivelyassociatedwithS100B levelsinhumanmilk(r=0.335,P=0.030,0.05).Inaddition,therewasasignificantcorrelationbetweenthelevelsofS100B proteinandBDNF(z=2.09,P=0.037,0.05).DeliverymodeswerenegativelyassociatedwiththeconcentrationofGDNFin humanmilk. Conclusions:S100Bprotein,BDNF,andGDNFarepresentinallsamplesofhumanmilk,andtheymayberesponsibleforthe longtermeffectsofbreastfeeding. Citation:LiR,XiaW,ZhangZ