Routine chest x-rays in intensive care units a systematic review and meta-analysis 英文参考文献.docVIP

Routine chest x-rays in intensive care units a systematic review and meta-analysis 英文参考文献.doc

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Routine chest x-rays in intensive care units a systematic review and meta-analysis 英文参考文献

Ganapathyetal.CriticalCare2012,16:R68 /content/16/2/R68 RESEARCH OpenAccess Routinechestx-raysinintensivecareunits: asystematicreviewandmeta-analysis AnusoumyaGanapathy1,NeillKJAdhikari2*,JamieSpiegelman3andDamonCScales2 Abstract Introduction:Chestx-rays(CXRs)arethemostfrequentradiologicaltestsperformedintheintensivecareunit (ICU).However,theutilityofperformingdailyroutineCXRsisunclear. Methods:WesearchedMedlineandEmbase(1948toMarch2011)forrandomizedandquasi-randomized controlledtrials(RCTs)andbefore-afterobservationalstudiescomparingastrategyofroutineCXRstoamore restrictiveapproachwithCXRsperformedtoinvestigateclinicalchangesamongcriticallyilladultsorchildren.In duplicate,weextracteddataontheCXRstrategy,studyqualityandclinicaloutcomes(ICUandhospitalmortality; durationofmechanicalventilationandICUandhospitalstay). Results:Ninestudies(39,358CXRs;9,611patients)wereincludedinthemeta-analysis.Threetrials(N=870)of moderatetogoodqualityprovidedinformationonthesafetyofarestrictiveroutineCXRstrategy;onlyonetrial systematicallyassessedformissedfindings.Pooleddatafromtrialsshowednoevidenceofeffectofarestrictive approachonICUmortality(riskratio[RR]1.04,95%confidenceinterval[CI]0.84to1.28,P=0.72;twotrials,N= 776),hospitalmortality(RR0.98,95%CI0.68to1.41,P=0.91;twotrials,N=259),ICUlengthofstay(weighted meandifference[WMD]-0.86days,95%CI-2.38to0.66days,P=0.27;threetrials,N=870),hospitallengthofstay (WMD-2.50days,95%CI-6.62to1.61days,P=0.23;twotrials,N=259),ordurationofmechanicalventilation (WMD-0.30days,95%CI-1.48to0.89days,P=0.62;threetrials,N=705).Addingdatafromsixobservational studies,oneofwhichsystematicallyscreenedformissedfindings,gavesimilarresults. Conclusions:Thismeta-analysisdidnotdetectanyharmassociatedwitharestrictivechestradiographstrategy. However,confidenceintervalswerewideandharmwasnotrigorouslyassessed.Therefore,thesafetyof abandoningroutineCXRsinpatientsadmittedtotheICUremainsuncertain. Introduction ventilation[2].AdvantagesofroutineCXRsmayinclude Physiciansof

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