rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal Cortex 英文参考文献.docVIP

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rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal Cortex 英文参考文献.doc

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rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal Cortex 英文参考文献

rTMSoftheLeftDorsolateralPrefrontalCortex ModulatesDopamineReleaseintheIpsilateralAnterior CingulateCortexandOrbitofrontalCortex SangSooCho1,2,AntonioP.Strafella1,2 * 1TorontoWesternResearchInstituteandHospital,UHN,UniversityofToronto,Toronto,Canada,2PETImagingCentre,CentreforAddictionandMentalHealth,University ofToronto,Toronto,Canada Abstract Background: Brain dopamine is implicated in the regulation of movement, attention, reward and learning and plays an importantroleinParkinson’sdisease,schizophreniaanddrugaddiction.Animalexperimentshavedemonstratedthatbrain stimulationisabletoinducesignificantdopaminergicchangesinextrastriatalareas.Giventheup-growinginterestofnon- invasivebrainstimulationaspotentialtoolfortreatmentofneurologicalandpsychiatricdisorders,itwouldbecriticalto investigatedopaminergicfunctionalinteractionsintheprefrontalcortexandmoreinparticulartheeffectofdorsolateral prefrontalcortex(DLPFC)(areas9/46)stimulationonprefrontaldopamine(DA). Methodology/PrincipalFindings:Healthyvolunteerswerestudiedwithahigh-affinityDAD2-receptorradioligand,[11C]FLB 457-PETfollowing10Hzrepetitivetranscranialmagneticstimulation(rTMS)oftheleftandrightDLPFC.rTMSontheleft DLPFCinducedasignificantreductionin[11C]FLB457bindingpotential(BP)intheipsilateralsubgenualanteriorcingulate cortex(ACC)(BA25/12),pregenualACC(BA32)andmedialorbitofrontalcortex(BA11).Therewerenosignificantchanges in[11C]FLB457BPfollowingrightDLPFCrTMS. Conclusions/Significance: To our knowledge, this is the first study to provide evidence of extrastriatal DA modulation following acute rTMS of DLPFC with its effect limited to the specific areas of medial prefrontal cortex. [11C]FLB 457-PET combined with rTMS may allow to explore the neurochemical functions of specific cortical neural networks and help to identifytheneurobiologicaleffectsofTMSforthetreatmentofdifferentneurologicalandpsychiatricdiseases. Citation:ChoSS,StrafellaAP(2009)rTMSoftheLeftDorsolateralPrefrontalCortexModulatesDopamineReleaseintheIps