Roles of the DYRK Kinase Pom2 in Cytokinesis, Mitochondrial Morphology, and Sporulation in Fission Yeast 英文参考文献.docVIP

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Roles of the DYRK Kinase Pom2 in Cytokinesis, Mitochondrial Morphology, and Sporulation in Fission Yeast 英文参考文献.doc

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Roles of the DYRK Kinase Pom2 in Cytokinesis, Mitochondrial Morphology, and Sporulation in Fission Yeast 英文参考文献

RolesoftheDYRKKinasePom2inCytokinesis, MitochondrialMorphology,andSporulationinFission Yeast PengchengWu1.¤,RanZhao1.,YanfangYe1,2,Jian-QiuWu1,2 * 1DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,Ohio,UnitedStatesofAmerica,2DepartmentofMolecularandCellularBiochemistry,TheOhio StateUniversity,Columbus,Ohio,UnitedStatesofAmerica Abstract Pom2 is predicted to be a dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) related to Pom1 in Schizosaccharomyces pombe. DYRKs share a kinase domain capable of catalyzing autophosphorylation on tyrosine and exogenousphosphorylationonserine/threonineresidues.HereweshowthatPom2isfunctionallydifferentfromthewell- characterized Pom1, although they share 55% identity in the kinase domain and the Pom2 kinase domain functionally complementsthatofPom1.Pom2localizestomitochondriathroughoutthecellcycleandtothecontractileringduringlate stagesofcytokinesis.Overexpressionbutnotdeletionofpom2resultsinseveredefectsincytokinesis,indicatingthatPom2 mightshareanoverlappingfunctionwithotherproteinsinregulatingcytokinesis.Gainandlossoffunctionanalysesreveal thatPom2isrequiredformaintainingmitochondrialmorphologyindependentlyofmicrotubules.Intriguingly,mostmeiotic pom2D cells form aberrant asci with meiotic and/or forespore membrane formation defects. Taken together, Pom2 is a novelDYRKkinaseinvolvedinregulatingcytokinesis,mitochondrialmorphology,meiosis,andsporulationinfissionyeast. Citation:WuP,ZhaoR,YeY,WuJ-Q(2011)RolesoftheDYRKKinasePom2inCytokinesis,MitochondrialMorphology,andSporulationinFissionYeast.PLoS ONE6(12):e28000.doi:10.1371/journal.pone.0028000 Editor:DanielLew,DukeUniversityMedicalCenter,UnitedStatesofAmerica ReceivedAugust1,2011;AcceptedOctober29,2011;PublishedDecember12,2011 Copyright:?2011Wuetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Fundin