Roles of Specific Membrane Lipid Domains in EGF Receptor Activation and Cell Adhesion Molecule Stabilization in a Developing Olfactory System 英文参考文献.docVIP

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Roles of Specific Membrane Lipid Domains in EGF Receptor Activation and Cell Adhesion Molecule Stabilization in a Developing Olfactory System 英文参考文献.doc

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Roles of Specific Membrane Lipid Domains in EGF Receptor Activation and Cell Adhesion Molecule Stabilization in a Developing Olfactory System 英文参考文献

RolesofSpecificMembraneLipidDomainsinEGF ReceptorActivationandCellAdhesionMolecule StabilizationinaDevelopingOlfactorySystem NicholasJ.Gibson*,LeslieP.Tolbert,LynneA.Oland ArizonaResearchLaboratoriesDivisionofNeurobiology,UniversityofArizona,Tucson,Arizona,UnitedStatesofAmerica Abstract Background:Reciprocalinteractionsbetweenglialcellsandolfactoryreceptorneurons(ORNs)causeORNaxonsentering the brain to sort, to fasciculate into bundles destined for specific glomeruli, and to form stable protoglomeruli in the developingolfactorysystemofanexperimentallyadvantageousanimalspecies,themothManducasexta.Epidermalgrowth factorreceptors(EGFRs)andthecelladhesionmolecules(IgCAMs)neuroglianandfasciclinIIareknowntobeimportant playersintheseprocesses. Methodology/PrincipalFindings:Wereportinsituandcell-culturestudiesthatsuggestaroleforglycosphingolipid-rich membrane subdomains in neuron-glia interactions. Disruption of these subdomains by the use of methyl-b-cyclodextrin resultsinlossofEGFRactivation,depletionoffasciclinIIinORNaxons,andlossofneuroglianstabilizationinthemembrane. Atthecellularlevel,disruptionleadstoaberrantORNaxontrajectories,smallantennallobes,abnormalarraysofolfactory glomerul,andlossofnormalglialcellmigration. Conclusions/Significance: We propose that glycosphingolipid-rich membrane subdomains (possible membrane rafts or platforms) are essential for IgCAM-mediated EGFR activation and for anchoring of neuroglian to the cytoskeleton, both requiredfornormalextensionandsortingofORNaxons. Citation:GibsonNJ,TolbertLP,OlandLA(2009)RolesofSpecificMembraneLipidDomainsinEGFReceptorActivationandCellAdhesionMoleculeStabilization inaDevelopingOlfactorySystem.PLoSONE4(9):e7222.doi:10.1371/journal.pone.0007222 Editor:AlainChe′dotal,InstitutdelaVision,France ReceivedJanuary23,2009;AcceptedSeptember6,2009;PublishedSeptember29,2009 Copyright: ? 2009 Gibson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permit