Rubiacordone A A New Anthraquinone Glycoside from the Roots of Rubia cordifolia 英文参考文献.docVIP

Molecules 2009, 14, 566-572; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Rubiacordone A: A New Anthraquinone Glycoside from the Roots of Rubia cordifolia Xiang Li 1,?, Zhi Liu 2, Yun Chen 3, Li-Juan Wang 1, Yi-Nan Zheng 1, Guang-Zhi Sun 2 and Chang-Chun Ruan 2,* 1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, P.R. China; E-mails: drxiang@ (X. L.); ljwang@ (L-J. W.); zhenyinan@ (Y-N. Z.) 2 Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, P.R. China; E-mails: jlndxdhs@126.com (Z. L.); gzsun1967@ (G-Z. S.) 3 Research Centre for Medical and Structural Biology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, P.R. China; E-mail: yunchen@ (Y. C.) ? Present address: Agriculture and Agri-Food Canada, Saskatoon Research Center, 107 Science Place, Saskatoon, SK, S7N 0X2, Canada * Author to whom correspondence should be addressed; E-mail: yuan.changchun1@; Tel.: +86-431-8451-0949; Fax: +86-431-8451-0409. Received: 20 November 2008; in revised form: 13 January 2009 / Accepted: 15 January 2009 / Published: 23 January 2009 Abstract: A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2- methylanthraquinone-3-O-α-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[α-L-rhamnopyranosyl- (1→2)-β-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria. Keywords: Rubia cordifolia; Rubiacordone A; Anthraquinone; Antimicrobial.  Molecules 2009, 14 567 Introduction Rubia cordifolia Linn (Rubiaceae) is a slender, branched, climbing plant, with very long cylindrical roots, wi