RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models 英文参考文献.docVIP

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RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models 英文参考文献.doc

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AIDS Research and Therapy BioMedCentral Research Open Access RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models Yonghou Jiang1, Baoping Tian1, Mohammed Saifuddin2, Michael B Agy1, Peter Emau1, J Scott Cairns3 and Che-Chung Tsai*1 Address: 1Washington National Primate Research Center, University of Washington, Box 357330 Health Sciences Building, Seattle, Washington 98195, USA, 2CONRAD, Eastern Virginia Medical School, Arlington, Virginia 22209, USA and 3Fifth Opus Consulting, LLC Mercer Island, Washington 98040, USA Email: Yonghou Jiang - yhjiang@; Baoping Tian - baoping@; Mohammed Saifuddin - msaifuddin@; Michael B Agy - magy@; Peter Emau - pemau@; J Scott Cairns - scottcairns@; Che- Chung Tsai* - cctsai@ * Corresponding author Published: 5 November 2009 Received: 4 July 2009 Accepted: 5 November 2009 AIDS Research and Therapy 2009, 6:23 doi:10.1186/1742-6405-6-23 This article is available from: /content/6/1/23 ? 2009 Jiang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important category of drugs for both chemotherapy and prevention of human immunodeficiency virus type 1 (HIV-1) infection. However, current non-human primate (NHP) models utilizing simian immunodeficiency virus (SIV) or commonly used chimeric SHIV (SIV expressing HIV-1 envelope) are inadequate due to the insensitivity to NNRTIs. To develop a NHP model for evaluation of NNRTI compounds, we characterized a RT-SHIV virus that was assembled by replacing the SIVmac239 reverse transcriptase (RT) with that of HIV-1HXB2. Since RT-SHIV