Role of Zebrafish Lbx2 in Embryonic Lateral Line Development 英文参考文献.docVIP

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Role of Zebrafish Lbx2 in Embryonic Lateral Line Development 英文参考文献.doc

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Role of Zebrafish Lbx2 in Embryonic Lateral Line Development 英文参考文献

RoleofZebrafishLbx2inEmbryonicLateralLine Development XiaowenChen1,2,QiyongLou1,2,JiangyanHe1,2,ZhanYin1,2 * 1KeyLaboratoryofAquaticBiodiversityandConservationofChineseAcademyofSciences,InstituteofHydrobiology,ChineseAcademyofSciences,Wuhan,Hubei,China, 2GraduateUniversityofChineseAcademyofSciences,Beijing,China Abstract Background: The zebrafish ladybird homeobox homologous gene 2 (lbx2) has been suggested to play a key role in the regulationofhypaxialmyogenicprecursorcellmigration.Unliketheirlbxcounterpartsinmammals,thefunctionofteleost lbxgenesbeyondmyogenesisduringembryonicdevelopmentremainsunexplored. PrincipalFindings:Abrogationoflbx2functionusingaspecificindependentmorpholinooligonucleotide(MO)ortruncated lbx2mRNAwithanengraileddomaindeletion(lbx2eh-)resultedindefectiveformationofthezebrafishposteriorlateralline (PLL).MigrationofthePLLprimordiumwasalteredandaccompaniedbyincreasedcelldeathintheprimordiumoflbx2-MO- injectedembryos.Adecreasednumberofmusclepioneercellsandimpairedexpressionpatternofsdf1ainthehorizontal myoseptumwasobservedinlbx2morphants. Significance: Injection of lbx2 MO or lbx2eh- mRNA resulted in defective PPL formation and altered sdf1a expression, confirming an important function for lbx2 in sdf1a-dependent migration. In addition, the disassociation of PPL nerve extensionwithPLLprimordialmigrationinsomelbx2morphantssuggeststhatpathfindingofthePLLprimordiumandthe laterallinenervemayberegulatedindependently. Citation: Chen X, Lou Q, He J, Yin Z (2011) Role of Zebrafish Lbx2 in Embryonic Lateral Line Development. PLoS ONE 6(12): e29515. doi:10.1371/ journal.pone.0029515 Editor:ChristophWinkler,NationalUniversityofSingapore,Singapore ReceivedFebruary5,2011;AcceptedNovember29,2011;PublishedDecember22,2011 Copyright: ? 2011 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearec