Regional Brain Stem Atrophy in Idiopathic Parkinsons Disease Detected by Anatomical MRI 英文参考文献.docVIP

RegionalBrainStemAtrophyinIdiopathicParkinson’s DiseaseDetectedbyAnatomicalMRI ThomasJubault1,2*,SimonaM.Brambati1,ClotildeDegroot1,Beno??tKullmann1,AntonioP.Strafella3, Anne-LouiseLafontaine4,SylvainChouinard5,OuryMonchi1,2 1Unite′ deNeuroimagerieFonctionelle,InstitutUniversitairedeGe′riatriedeMontre′al,Montreal,Quebec,Canada,2De′partement deRadiologie,Universite′ deMontreal, Montreal,Quebec,Canada,3TorontoWesternHospital/ResearchInstituteCAMH-PETImagingCentre,UniversityofToronto,Toronto,Ontario,Canada, 4Movement DisordersUnit,McGillUniversityHealthCenter,Montreal,Quebec,Canada,5Unite′desDe′sordresduMouvement,Centrehospitalierdel’Universite′deMontre′al,Montreal, Quebec,Canada Abstract Idiopathic Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the dysfunction of dopaminergic dependent cortico-basal ganglia loops and diagnosed on the basis of motor symptoms (tremors and/or rigidity and bradykinesia). Post-mortem studies tend to show that the destruction of dopaminergic neurons in the substantia nigra constitutes an intermediate step in a broader neurodegenerative process rather than a unique feature of Parkinson’s disease,asaconsistentpatternofprogressionwouldexist,originatingfromthemedullaoblongata/pontinetegmentum.To date, neuroimaging techniques have been unable to characterize the pre-symptomatic stages of PD. However, if such a regularneurodegenerativepatternweretoexist,consistentdamageswouldbefoundinthebrainstem,evenatearlystages ofthedisease.Werecruited23PDpatientsatHoennandYahrstagesItoIIofthediseaseand18healthycontrols(HC) matched for age. T1-weighted anatomical scans were acquired (MPRAGE, 1 mm3 resolution) and analyzed using an optimizedVBMprotocoltodetectwhiteandgreymattervolumereductionwithoutspatialapriori.WhentheHCgroupwas comparedtothePDgroup,asingleclusterexhibitedstatisticaldifference(p,0.05correctedforfalsedetectionrate,4287 mm3)inthebrainstem,betweentheponsandthemedullaoblongata.Thepresentstudyprovidesin