Retrospective Study of the Incidence of HFMD and Seroepidemiology of Antibodies against EV71 and CoxA16 in Prenatal Women and Their Infants 英文参考文献.docVIP

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Retrospective Study of the Incidence of HFMD and Seroepidemiology of Antibodies against EV71 and CoxA16 in Prenatal Women and Their Infants 英文参考文献.doc

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Retrospective Study of the Incidence of HFMD and Seroepidemiology of Antibodies against EV71 and CoxA16 in Prenatal Women and Their Infants 英文参考文献

RetrospectiveStudyoftheIncidenceofHFMDand SeroepidemiologyofAntibodiesagainstEV71and CoxA16inPrenatalWomenandTheirInfants Feng-CaiZhu1*.,Zheng-LunLiang2*.,Fan-YueMeng1.,YingZeng3,Qun-YingMao2,KaiChu1 ,Xue- FangSong3,XinYao2,Jing-XinLi1,HongJi1,Yi-JuZhang1,LiangLi1,Hong-XingPan1,KeXu1 ,Wei- MingDai1,Wei-WeiZhang4,FeiDeng1,HuaWang1,Jun-ZhiWang2* 1Acute Infectious Disease Control and Prevention,JiangsuProvincial Center for Disease Control and Prevention, Nanjing, People’sRepublic ofChina, 2Laboratory 2, NationalInstitutesforFoodandDrugControl,Beijing,People’sRepublicofChina,3ShenzhenKangtaiBiologicalProductsCo.,Ltd.,ShenzhenScienceIndustryPark, GuangdongProvince,People’sRepublicofChina,4SchoolofPublicHealth,SoutheastUniversity,Nanjing,JiangsuProvince,People’sRepublicofChina Abstract Background:Hand,foot,andmouthdisease(HFMD)hasbeenemergingasanimportantpublicproblemoverthepastfew decades, especially in Asian and Pacific regions. A national program on EV71 vaccine development against HFMD was initiatedinChina,in2008,whichcalledforaneedforseroepidemiologicalstudyforthetargetpopulation. Methodology/Principal Findings: This was a retrospective study conducted in Jiangsu Province, in October, 2010. We measuredtheneutralizingantibodiesagainstEV71andCoxA16inacohortofinfantsagedof2,7,12,and27–38months andtheirmothersjustbeforedelivery.Seriesserasamplesfrom975infantsand555motherswerecollectedandanalyzed. QuestionnairesonthehistoryofHFMDwerecompletedinthesurvey.Atotalof143HFMDcaseswerecollected,butonly 11.2%werereportedtotheNationalInfectiousDiseaseInformationManagementSystem.Thelevelofmaternalantibody titers decreased dramatically during the first 7 month and remained at a relatively low level thereafter. But it increased significantly from month 12 to months 27–38. The accumulate incidence density of HFMD demonstrated a significant increaseafter14monthsofage,resultinginaaccumulateincidencedensityof50.8/1000person-years insurveyperiod. SeropositivityofEV71antibodyininf