Routine prophylactic antibiotic use in the management of snakebite 英文参考文献.docVIP

BMC Clinical Pharmacology BioMedCentral Research article BMC2001Clinical, 1 Pharmacology :4 Routine prophylactic antibiotic use in the management of snakebite Dexter D Tagwireyi1, Douglas E Ball*1 and Charles FB Nhachi2 Address: 1Drug and Toxicology Information Service, Department of Pharmacy, University of Zimbabwe, Box A178, Avondale, Harare, Zimbabwe and 2Department of Clinical Pharmacology, Medical School, University of Zimbabwe, Box A178, Avondale, Harare, Zimbabwe E-mail: Dexter D Tagwireyi - dtagwireyi@healthnet.zw; Douglas E Ball* - dball@healthnet.zw; Charles FB Nhachi - cnhachi@healthnet.zw *Corresponding author Published: 2 November 2001 Received: 11 September 2001 Accepted: 2 November 2001 BMC Clinical Pharmacology 2001, 1:4 This article is available from: /1472-6904/1/4 ? 2001 Tagwireyi et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any non- commercial purpose, provided this notice is preserved along with the articles original URL. For commercial use, contact info@ Abstract Background: Routine antibiotic prophylaxis following snakebite is not recommended but evidence suggests that it may be common practice in Zimbabwe. This study set out to determine and describe the extent of this practice at Parirenyatwa Hospital, a large teaching hospital in Zimbabwe Methods: A retrospective case review (1996 to 1999 inclusive) of all cases of snakebite was undertaken at Parirenyatwa Hospital. Cases with a diagnosis of snakebite, presenting within 24 hours of the bite and with no complications or concurrent illness were defined as routine prophylactic antibiotic use. Results: From 78 cases which satisfied the inclusion criteria, 69 (88.5%) received antibiotics. Ten different antibiotics from 6 different classes were used with penicillins the most commonly prescribed (benzylpenicillin in 29% of cases, alone or in