Role of Type II Protein Arginine Methyltransferase 5 in the Regulation of Circadian Per1 Gene 英文参考文献.docVIP

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Role of Type II Protein Arginine Methyltransferase 5 in the Regulation of Circadian Per1 Gene 英文参考文献.doc

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Role of Type II Protein Arginine Methyltransferase 5 in the Regulation of Circadian Per1 Gene 英文参考文献

RoleofTypeIIProteinArginineMethyltransferase5in theRegulationofCircadianPer1Gene JungtaeNa1,KwanghyunLee1,Hwan-GonKim1,Jee-YoonShin1,WonhoNa1,HayanJeong1 ,Jong- WooLee1,SehyungCho2,Won-SunKim1,Bong-GunJu1* 1DepartmentofLifeScience,SogangUniversity,Seoul,Korea,2DepartmentofPhysiology,KyungHeeUniversitySchoolofMedicine,Seoul,Korea Abstract Circadianclocksaretheendogenousoscillatorsthatregulaterhythmicphysiologicalandbehavioralchangestocorrespond to daily light-dark cycles. Molecular dissections have revealed that transcriptional feedback loops of the circadian clock genesdrivethemolecularoscillation,inwhichPER/CRYcomplexesinhibitthetranscriptionalactivityoftheCLOCK/BMAL1 heterodimer to constitute a negative feedback loop. In this study, we identified the type II protein arginine methyltransferase5(PRMT5)asaninteractingmoleculeofCRY1.AlthoughthePrmt5genewasconstitutivelyexpressed, increasedinteractionofPRMT5withCRY1wasobservedwhenthePer1genewasrepressedbothinsynchronizedmouse liverandNIH3T3cells.Moreover,rhythmicrecruitment ofPRMT5andCRY1tothePer1 genepromoterwasfoundtobe associatedwithanincreasedlevelofhistoneH4R3dimethylationandPer1generepression.Consistently,decreasedhistone H4R3 dimethylation and altered rhythmic Per1 gene expression were observed in Prmt5-depleted cells. Taken together, these findings provide an insight into the link between histone arginine methylation by PRMT5 and transcriptional regulationofthecircadianPer1gene. Citation:NaJ,LeeK,KimH-G,ShinJ-Y,NaW,etal.(2012)RoleofTypeIIProteinArginineMethyltransferase5intheRegulationofCircadianPer1Gene.PLoS ONE7(10):e48152.doi:10.1371/journal.pone.0048152 Editor:NicholasS.Foulkes,KarlsruheInstituteofTechnology,Germany ReceivedMarch26,2012;AcceptedSeptember20,2012;PublishedOctober25,2012 Copyright:?2012Naetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcear