Safety of the Recombinant Cholera Toxin B Subunit, Killed Whole-Cell (rBS-WC) Oral Cholera Vaccine in Pregnancy 英文参考文献.docVIP

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Safety of the Recombinant Cholera Toxin B Subunit, Killed Whole-Cell (rBS-WC) Oral Cholera Vaccine in Pregnancy 英文参考文献.doc

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SafetyoftheRecombinantCholeraToxinBSubunit, KilledWhole-Cell(rBS-WC)OralCholeraVaccinein Pregnancy RamadhanHashim1,AhmedM.Khatib2,GodwinEnwere3,JinKyungPark1,RitaReyburn1, MohammadAli1,NaYoonChang1,DeokRyunKim1,BenediktLey1,4,KamalaThriemer1 ,Anna LenaLopez1,JohnD.Clemens1,JacquelineL.Deen1,SunheangShin1,ChristianSchaetti5,6, RaymondHutubessy3,MariaTeresaAguado3,MariePauleKieny3,DavidSack7,StephenObaro8, AttiyeJ.Shaame2,SaidM.Ali9,AbdulA.Saleh2,LorenzvonSeidlein10*,MohamedS.Jiddawi2 1International Vaccine Institute, Seoul, Korea, 2Ministry of Health and Social Welfare, Stonetown, Zanzibar, 3World Health Organization, Geneva, Switzerland, 4Biocenter,UniversityofVienna,Vienna,Austria,5SwissTropicalandPublicHealthInstitute,Basel,Switzerland,6UniversityofBasel,Basel,Switzerland,7JohnsHopkins School ofPublicHealth,Baltimore, Maryland,United StatesofAmerica, 8Michigan StateUniversity,EastLansing,Michigan, United StatesofAmerica, 9PublicHealth LaboratoryIvodeCarneri,Chake-Chake,Zanzibar,10MenziesSchoolofHealthResearch,Casuarina,NorthernTerritory,Australia Abstract Introduction:Massvaccinationsareamainstrategyinthedeploymentoforalcholeravaccines.Campaignsavoidgiving vaccinetopregnantwomenbecauseoftheabsenceofsafetydataofthekilledwhole-celloralcholera(rBS-WC)vaccine. Balancingthisconcernistheknownhigherriskofcholeraandofcomplicationsofpregnancyshouldcholeraoccurinthese women,aswellasthelackofexpectedadverseeventsfromakilledoralbacterialvaccine. Methodology/Principal Findings:FromJanuarytoFebruary2009,amassrBS-WCvaccinationcampaignofpersonsover two years of age was conducted in an urban and a rural area (population 51,151) in Zanzibar. Pregnant women were advisednottoparticipateinthecampaign.Morethanninemonthsafterthelastdoseofthevaccinewasadministered,we visited all women between 15 and 50 years of age living in the study area. The outcome of pregnancies that were inadvertentlyexposedtoatleastoneoralcholeravaccinedoseandthosethatwerenotexposedwasevaluated.13,736 (94%)o