Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors 英文参考文献.docVIP

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Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors 英文参考文献.doc

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Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors 英文参考文献

SeasonofBirthandDopamineReceptorGene AssociationswithImpulsivity,SensationSeekingand ReproductiveBehaviors DanT.A.Eisenberg1,2,3,4*,BenjaminCampbell5,JamesMacKillop6,7,J.KojiLum2,3,4,DavidS.Wilson2,3 1DepartmentofAnthropology,NorthwesternUniversity,Evanston,Illinois,UnitedStatesofAmerica,2DepartmentofAnthropology,StateUniversity ofNewYorkatBinghamton,Binghamton,NewYork,UnitedStatesofAmerica,3DepartmentofBiology,StateUniversityofNewYorkatBinghamton, Binghamton, New York, United States of America, 4Laboratory of Evolutionary Anthropology and Health, State University of New York at Binghamton, Binghamton, New York, United States of America, 5Department of Anthropology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin,UnitedStatesofAmerica,6DepartmentofPsychology,StateUniversityofNewYorkatBinghamton,Binghamton,NewYork,UnitedStates ofAmerica,7CenterforAlcoholandAddictionStudies,BrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica Background.Seasonofbirth(SOB)hasbeenassociatedwithmanyphysiologicalandpsychologicaltraitsincludingnovelty seekingandsensationseeking.Similartraitshavebeenassociatedwithgeneticpolymorphismsinthedopaminesystem.SOB anddopaminereceptorgeneticpolymorphismsmayindependentlyandinteractivelyinfluencesimilarbehaviorsthroughtheir common effects on the dopaminergic system. Methodology/Principal Findings. Based on a sample of 195 subjects, we examined whether SOB was associated with impulsivity, sensation seeking and reproductive behaviors. Additionally we examinedpotentialinteractionsofdopaminereceptorgeneswithSOBforthesamesetoftraits.Phenotypeswereevaluated using the Sociosexual Orientation Inventory, the Barratt Impulsivity Scale, the Eysenck Impulsivity Questionnaire, the SensationSeekingScale,andtheDelayDiscountingTask.Subjectswerealsoaskedabouttheirageatfirstsexaswellastheir desiredageatthebirthoftheirfirstchild.ThedopaminegenepolymorphismsexaminedwereDopamineReceptorD2(DRD2) TaqI A and D4 (DRD4) 48bp VNTR. Primary analyses included fa