Seasonal Changes in Mood and Behavior Are Linked to Metabolic Syndrome 英文参考文献.docVIP

SeasonalChangesinMoodandBehaviorAreLinkedto MetabolicSyndrome ReetaRintama¨ki1.,SharonGrimaldi1.,AniEnglund1.,JariHaukka1,TimoPartonen1*,AnttiReunanen2,ArpoAromaa2,JoukoLo¨nnqvist1,3 1Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland, 2Department of Health and Functional Capacity,NationalPublicHealthInstitute,Helsinki,Finland,3DepartmentofPsychiatry,HelsinkiUniversityHospital,Helsinki,Finland Background.Obesityisamajorpublichealthproblemworldwide.Metabolicsyndromeisariskfactortothecardiovascular diseases.Ithasbeenreportedthatdisruptionsofthecircadianclockworkareassociatedwithandmaypredisposetometabolic syndrome. Methodology and Principal Findings. 8028 individuals attended a nationwide health examination survey in Finland.Datawerecollectedwithaface-to-faceinterviewathomeandduringanindividualhealthstatusexamination.The waist circumference, height, weight and blood pressure were measured and samples were taken for laboratory tests. Participants were assessed using the ATP-III criteria for metabolic syndrome and with the Seasonal Pattern Assessment Questionnairefortheirseasonalchangesinmoodandbehavior.Seasonalchangesinweightinparticularwereariskfactorof metabolic syndrome, after controlling for a number of known risk and potential confounding factors. Conclusions and Significance.Metabolicsyndromeisassociatedwithhighglobalscoresontheseasonalchangesinmoodandbehavior,and with those in weight in particular. Assessment of these changes may serve as a useful indicator of metabolic syndrome, because of easy assessment. Abnormalities in the circadian clockwork which links seasonal fluctuations to metabolic cycles maypredisposetoseasonalchangesinweightandtometabolicsyndrome. Citation: Rintama¨ki R,GrimaldiS,EnglundA,HaukkaJ,PartonenT,etal(2008)SeasonalChangesinMoodandBehaviorAreLinkedtoMetabolic Syndrome.PLoSONE3(1):e1482.doi:10.1371/journal.pone.0001482 INTRODUCTION or MOP9). These proteins heterodimerize and the subsequen